HPTLC DETERMINATION OF SORAFENIB TOSYLATE IN BULK DRUG AND PHARMACEUTICAL DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
A simple and sensitive HPTLC method has been developed for the quantitative estimation of Sorafenib Tosylate in bulk and Pharmaceutical dosage form. Sorafenib Tosylate was chromatographed on silica Gel 60 F254 TLC plate using n-Hexane : isopropanol (8:2 v/v) as mobile phase. Sorafenib Tosylate showed Rf value 0.34±0.05 and scanned at 254 nm using Camag TLC Scanner 3. The method was validated in terms of linearity (100–500 ng/spot), precision (intra-day % RSD variation 0.07 to 0.39%, inter-day % RSD variation 0.5 to 1.2%), accuracy (98.88 to 100.815%) specificity, ruggedness, sensitivity and reproducibility. The limit of detection and limit of quantitation for Sorafenib Tosylate were found to be 1.57 ng/spot and 4.75 ng/spot, respectively. The developed method was successfully used for the assay of Sorafenib Tosylate in bulk and Pharmaceutical dosage form.. it can be used for the routine quality control testing of marketed formulations.
Authors and Affiliations
Amol Powar , Pramila Gowda
Keywords
Related Articles
- EP ID EP135066
- DOI -
- Views 78
- Downloads 0
A CONCEPTUAL APPROACH OF PSYCHOSOMATIC DISORDERS (MANODAHIC VYADHIYAN)
Psychosomatic means psyche (mind) and soma (body) - A psychosomatic disorder is a disease which involves both mind and body. Some physical diseases are thought to be particularly prone to be made worse by mental factors...
TAKE SOYBEAN TO REMAIN EVERGREEN
Soybean is well-recognized for its food value because of its high protein content. Soy consumption reduces the risk of developing breast, prostate and/or colon cancer. It reduces total cholesterol, LDL and triglyceride l...
MANAGEMENT OF MALE INFERTILITY: AYURVEDIC APPROACH
An estimated 5-10 percent of couples are classified as infertile, which means that they have been trying to get pregnant with frequent, unprotected intercourse for at least a year with no success. In about half the cases...
FORMULATION AND EVALUATION OF TRANSDERMAL PATCH OF SERTACONAZOLE NITRATE
The present work was designed to develop suitable transdermal matrix patch of sertaconazole nitrate, which is of the imidazole class used for antifungal medication, using Ethyl cellulose (EC), Po...
IN-VITRO STUDY OF ENTAMOEBA HISTOLYTICA WITH COCONUT JUICE ACT AS AN ANTIAMOEBIC AGENT AT DIFFERENT CONCENTRATION IN NIH MEDIUM
Amoebiasis is a parasitic infection caused by Entamoeba histolytica. It is usually contracted by ingesting water or food contaminated with amoebic cysts. Amoebiasis is an intestinal infection that may or may not be sympt...