HPV and HIV Infection in Women with Precancerous and Cancerous Lesions of Uterine Cervix
Journal Title: Pan Asian Journal of Obstetrics & Gynecology - Year 2018, Vol 1, Issue 1
Abstract
Background: Globally, 500,000 new cases of cancer of the uterine cervix are recorded annually, nearly 20% are from India. Numerous clinical and experimental studies have established an association between HPV and cervical cancer. Most immune responses are important in resolution of HPV infection; hence, women with HIV are more likely to have severe, frequent HPV disease. Considering the increasing incidence of HIV in India, an increase in cervical abnormalities and cervical cancer can be expected in the near future. This study was thus carried out to study the prevalence and association of HPV and HIV co-infection in women with precancerous and cancerous lesions of cervix. Design: Cross-sectional study. Aims: To study the prevalence and correlation of HPV and HIV infection in women with cervical intraepithelial neoplasia and cervical cancer. Materials and methods: Sexually active women attending the Gynecology OPD and IPD with sign and symptoms suggestive of cervical pathology were subjected to cytology, colposcopy, and biopsy. Cervical samples for HPV detection and blood samples for HIV detection were taken. Statistical analysis: Chi-square test for statistical significance. Results: 254 women were enrolled based on signs and symptoms.143 women returned for follow-up. 129 were subjected to cervical biopsy and HPV testing of cervical tissue. HPV positivity in low-grade squamous intra-epithelial lesions (LSIL), high-grade squamous intraepithelial lesions (HSIL) and cervical cancer was 60%, 100% and 93.1% respectively. None of the women tested were reactive for HIV Conclusion: For early detection and identification of high-risk population with precancerous lesions, there is a need for incorporation of HPV testing along with cytology to screen women. In view of the spreading HIV infection in India, we need to increase surveillance for HIV positive cases and increase awareness regarding prevention of HIV infection.
Authors and Affiliations
Sumedha Sharma
Keywords
Related Articles
- EP ID EP545984
- DOI -
- Views 172
- Downloads 0
Female Genital Tuberculosis Diagnosis to Treatment
Genital tuberculosis in females (FGTB) is a significant cause of morbidity. Mycobacterium tuberculosis is a causative agent for tuberculosis (TB). In majority of cases tubes are involved in almost 90-100% of cases. Endom...
Caesarean Section on Demand: Dilemma between Ethics and Autonomy
Caesarean section on demand (CSOD) has recently gained attention as first caesarean is the most important determinant of subsequent caesarean sections. Although vaginal birth is thought to be safer, caesarean section has...
Plexiform Tumorlets of Uterus: A Case Report
Plexiform leiomyoma, a variant of epithelioid leiomyoma of the uterus is an incidental finding in hysterectomy specimens. Small plexiform leiomyomas that are detected only on microscopic examination are referred to as pl...
Postpartum Depression—An Overview
Peripartum is the time when a female is most vulnerable to develop mental illness. Postpartum depression (PPD) is the most common psychiatric morbidity seen during this period. Prevalence of PPD is higher in developing c...
Lights, Camera, Action and … Ergonomics in Gynecology Laparoscopy
Gynecology laparoscopy surgeries have several patient related benefits. It is time to address the ergonomic challenges and consequently health impact on surgeons as a result of performing laparoscopic surgeries.