hsCRP in Pre-Hypertension And Hypertension: A Cross Sectional Study
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 2
Abstract
Abstract: Hypertension is turned into a leading cause of non-communicable disease associated mortality and morbidity in both developing as well as developed world. Hypertension is reported to be the fourth contributor to premature death in developed countries and the seventh in developing countries. The purpose of the study was to analyze the correlation between plasma hsCRP and lipid profile in pre-hypertensive as well as hypertensive in Indian patients, attending Diabetic clinic at Index Hospital, Indore and normal control subjects from within campus and surrounding areas. A total of 150 in which 50 newly diagnosed hypertensives (age and sex matched), 50 pre-hypertensives (age and sex matched) and 50 normo-tensive healthy subjects (age and sex matched) were selected for the study. The mean hsCRP value of pre-hypertensive group was higher than the control group and hypertensive group. The mean hsCRP value of pre-hypertensive group was also significantly higher than the hypertensive group. On comparing the parameters of lipid profile among the three study groups, mean cholesterol levels was highest in hypertensive group followed by pre-hypertensive and lowest in control group. These differences however were not significant statistically. Similarly the differences in mean values of LDL were also statistically non significant. Mean HDL level was highest in hypertensive group followed by normal group and lowest in pre-hypertensive group. The difference in mean HDL levels on comparing control group with pre-hypertensive groups and pre-hypertensive group with hypertensive group was highly significant (p<0.001). But there was no significant difference in mean HDL values of control and hypertensive groups. Thus HDL was lowest in prehypertensive group. In conclusion, our results suggest that increased serum CRP levels are associated with hypertension, more significantly with prehypertension and in new onset patients with hypertension. Thus serum CRP estimation can be a potential tool for early identification of individuals at the risk for development of hypertension and eventually CVDs.
Authors and Affiliations
Dr. Sonali Mishra, Dr. Pragati Khanorkar, Dr. Sachin Mishra, Dr. Prashant Peshattiwar, Dr. B K Agrawal
Keywords
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