HSP27 and Atherogenic Index of the Plasma - heralding cardiovascular complications inIndian diabetic subjects
Journal Title: Journal of Endocrinology and Diabetes - Year 2017, Vol 4, Issue 5
Abstract
Aim: To evaluate the importance of Heat shock protein 27 (HSP27) and Atherogenic Index of the Plasma (AIP) in diabetic subjects, as indicators of cardiovascular disease progression in diabetic subjects. Materials and Methods: 144 subjects were recruited in 4 different groups as follows: Group A1- diabetic > 5 years and hypertensive (N = 55), Group A2 – diabetic < 2 years (N = 28), Group B1 – hypertensive (N = 31) and Group B2 – healthy controls (N = 30). Anthropometric measurements were made and blood biochemistry profiles were established using standard protocols. AIP was calculated as Log (Triglycerides / HDL cholesterol),while HSP27 was measured using ELISA. Results: HSP27 varied significantly across the groups (one-way ANOVA, (F (3) = 4.95, p = 0.003). We saw significant increase in HSP27 levels between Groups A1 and B2, Groups A2 and B2, Groups A1 and B1, and Groups A2 and B1 (p= 0.001, 0.025, 0.003 and 0.043 respectively). AIP scores increased across the groups, although not significantly (one-way ANOVA, F (3) = 1.8, p = 0.15).The frequency of high risk AIP scores were more in Groups A1 and A2 as compared to the controls. HSP27 was negatively correlated with the AIP score, (Pearson’s coefficient = -0.173, p = 0.039). Two models of multivariate linear regression revealed that HSP27 and post prandial blood sugar (PPBS) were significant risk factors of AIP; F (5, 138) = 3.069, p = 0.012, R2 = 0.10. (Model 1, t = -2.591, p = 0.011; 95% CI = -0.269 to -0.036 and model 2, t = -2.332, p = 0.021; 95% CI = -0.256 to -0.021). Conclusion: Serum HSP27 and AIP increase in diabetic subjects with or without hypertension. The risk of cardiovascular complications can be monitored using HSP27.
Authors and Affiliations
Sudha S. Deo, Prashant S. Ratnaparkhi, Namrata B. Kulkarni, Meghana U. Ganu, Sanjay G. Godbole
Keywords
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- EP ID EP334005
- DOI 10.15226/2374-6890/4/5/00189
- Views 89
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