hsTropI: an early biomarker of acute coronary syndrome & MI
Journal Title: International Journal of Medical Research and Review - Year 2017, Vol 5, Issue 1
Abstract
In the Emergency Department cardiac troponins are the preferred biomarkers for the diagnosis of acute myocardial infarction (MI) and are useful for risk stratification of patients with acute coronary syndrome (ACS) and stable ischemic heart disease. The introduction of ‘high sensitivity’ Troponins (hscTn) in many tertiary care centers has transformed the diagnostic scenario, wherein, the time from onset of chest pain to its diagnosis has significantly been reduced. With the advent of new hsTnI assays, which have a low limit of detection, low imprecision and low reference limits, the possibility of more patients with unstable angina being classified as having non-ST-elevation myocardial infarction (NSTEMI) will now increase. Its use will identify more high-risk patients with undifferentiated chest pain, that will help ‘rule-in’ or ‘rule-out’ acute myocardial infarction. In conclusion, it may be said that hsTropI is a sensitive, albeit less specific marker of MI. In patients of mildly elevated hsTropI and without evidence of ST elevation, a serial assessment of the biomarker is suggested. This will likely translate into more improved outcomes in this difficult patient population when ECG findings and clinical presentation do not suggest a clear diagnosis.
Authors and Affiliations
Sohini Sengupta Neogi, Raj Kumar Kapoor
Skill based training of accredited social health activists: training effectiveness assessment using training and programme evaluation model
Background: Accredited Social Health Activists (ASHAs) are gross root health workers introduced under NRHM; for delivery of health services in rural areas. Training them for capacity building and functioning was a big ch...
Sexual dimorphism in ratio of second and fourth phalanges and metacarpals: A retrospective study
Introduction: There are many features in humans which exhibit sexual dimorphism. A unique feature showing this gender differentiation is the ratio of lengths of index and ring fingers. Sexual dimorphism in finger lengths...
Spontaneous bacterial peritonitis: risk factors and relationship to serum-ascites albumin gradient in chronic liver disease patient
Background: Spontaneous bacterial peritonitis (SBP) is probably the best characterized infectious complication that develops in patients with cirrhosis and ascites. Aims and objective: The present study was done to find...
Rare Entities of Mixed Phenotypic Acute Leukemia: Are They Really So Rare? Largest Series of B+T MPAL
Background: MPAL are rare, accounts 4% of acute leukemias. B+T MPAL are extremely rare. There is no robust information on the clinical and biologic features of these leukemias. Present study from kidwai memorial institut...
Utility of color Doppler in diagnosing ureteric calculi: a useful adjunct
Background: Renal colic is a common presenting complaint in patients report to the out patient department. Usually the first investigation these patients undergo is ultrasound because of its widespread availability. Usin...