Human Epidermal Growth Factor Receptor-3 mRNA Expression as a Prognostic Marker for Invasive Duct Carcinoma not Otherwise Specified
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 2
Abstract
Introduction: Breast cancer is the most common cancer in women and the Erythroblastosis Oncogene B(ErbB) receptor family holds crucial role in its pathogenesis. Human Epidermal Growth Factor Receptor 3 (HER-3) gene over expression in breast tissue has been associated with aggressive clinical behaviour and bad prognosis. Aim: To evaluate HER-3 mRNA expression level as a prognostic marker for breast cancer and to correlate its level with other established prognostic parameters. Materials and Methods: This study was carried out on specimens of 100 cases that were divided into 40 patients presented with fibroadenoma and 60 patients presented with Invasive Ductal Carcinoma (IDC) not otherwise specified and underwent modified radical mastectomy. All specimens were investigated for HER-2/neu, ER and PR expression by Immunohistochemistry (IHC) and quantitative assay of HER-3 mRNA expression using real time PCR technique. Results: There was a significant high HER3 mRNA level in carcinoma cases compared to fibroadenoma. In malignant cases, HER3 mRNA level was significantly associated with advanced T stage, advanced N stage, number of positive lymph nodes, large tumour size and cases associated with an adjacent in situ component. Moreover, HER-3 mRNA level was of highest values in Her-2/neu positive group followed by triple negative cases with the lowest level in luminal group (p<0.05). Conclusion: HER-3 gene is upregulated in IDC especially those carrying poor prognostic features. HER-3 mRNA level may identify a subset of patients with a poor prognosis, and who could undergo further evaluation for the efficacy of HER3 targeted anticancer therapy
Authors and Affiliations
Ghada Ezat Hammoda, Sally Mohammed El-Hefnawy, Asmaa Gaber Abdou, Rania Abdallah Abdallah
Keywords
Related Articles
- EP ID EP333244
- DOI 10.7860/JCDR/2017/23812.9442
- Views 84
- Downloads 0
General Public and Community Pharmacists Perception on Counterfeit Medicines: A Preliminary Crosssectional Study in Qatar
ABSTRACT Introduction: One major contributing factor to the prevalence of counterfeit medicines in a country is the lack of knowledge and awareness of the society. Information on general public and healthcare professiona...
Accuracy of Sonographic Modules in the Estimation of Birth Weight: An Analytical Study of Antenatal Women in Enugu, Nigeria
ABSTRACT Introduction: Antenatal sonographic estimation of foetal weight is a common practice. The use of these estimates to predict actual birth weight is crucial for appropriate management of certain pregnancy conditio...
Dermato-Lymphangitis in Filariasis Resembles Infected Chronic Venous Insufficiency: Two Case Reports and Review of Literature
ABSTRACT Chronic lower limb swelling is frequently encountered in clinical practice. Secondary lymphoedema and chronic venous insufficiency are two frequent causes of chronic lower limb swelling. The most common form of...
Fabrication of Conventional Complete Denture in Resorbed Mandibular Ridge with Deficient Keratinized Mucosa Using Free Gingival Graft
ABSTRACT Long standing edentulism often results in dimensional changes in the bone as well as in the soft tissue. The severity of these changes depends upon the span of edentulism, systemic and oral well-being of the pat...
Assessment of Diastolic Dysfunction Parameters and Cardiac Chamber Size in Smokers with COPD: A Case Control Study
ABSTRACT Introduction: Chronic Obstructive Pulmonary Disease (COPD) is a critical health care burden across the globe. Pulmonary Hypertension (PH) is a widespread feature of advanced COPD and is estimated to affect 20% o...