Human Immunodeficiency Virus infection and cardiovascular disease
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH IN MEDICAL SCIENCES - Year 2017, Vol 3, Issue 9
Abstract
The human immunodeficiency virus (HIV) is a retrovirus belonging to the family of lentiviruses. Retroviruses are so named because they reverse the normal flow of genetic information. In all cellular organisms the genetic material is DNA. Retroviruses use their RNA and host DNA to make viral DNA. Infection with HIV causes severe damage to the immune system leading to Acquired Immune Deficiency Syndrome (AIDS). Individuals infected with HIV show both cellular and humoral (antibody) immune responses to the virus, but these responses are unable to prevent the ultimate progression of disease in the great majority of infected individuals. Depletion of CD4 lymphocytes is the hallmark of HIV infection, and predicts an individual's risk for infection with opportunistic pathogens as well as other complications of HIV disease. There is a great association of HIV and cardiovascular disease due to a higher prevalence of underlying traditional cardiovascular risk factors that are mostly host dependent. Most of the HIV drugs increase the chances of cardiovascular diseases in the patients especially protease inhibitors. Chronic inflammation, hypercoagulability and platelet activation all contribute to endothelial dysfunction, and are a probable link between HIV and cardiovascular disease.
Authors and Affiliations
Obeagu Emmanuel Ifeanyi1 , Amilo Grace I. 2 , Obeagu Getrude Uzoma3 and Nnatuanya Isaac N. 4
Keywords
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- EP ID EP564657
- DOI 10.22192/ijcrms.2017.03.09.002
- Views 118
- Downloads 0
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