Human Papilloma Viruses (HPV) and Human Cancers: Experience from a Regional Cancer Research Centre, Gujarat
Journal Title: GUJARAT CANCER SOCIETY RESEARCH JOURNAL - Year 2017, Vol 19, Issue 2
Abstract
To detect the etiological role of HPVs in patients with head and neck cancers from tissues. A total of 363 (100 head and neck cancers, and 263 cervical cancer patients) patients were included in the study and tissue biopsy was taken for histopathology and molecular studies by multiplex PCR. Out of 100 cases of Head & Neck cancers, the HPV was detected in 20% of cases. High risk HPV 16 was detected in 35% of SCC of oral & oropharyngeal cancers. 65% of other types of HPV were detected like; HPV-33 (15%), HPV-39 (5%), HPV-45 (10%), HPV-52 (20%) and HPV-58 (15%). Among Cervical cancer patients, overall 57.41% of the patients showed presence of HPV. HPV was found in 71.4% , 43.4%, and 2.27% in Cervical cancer, CIN and Control groups respectively. Out of 263 cervical cancers, positivity of different HPV types were, HPV-16 (60%), HPV-18 (2.85%), HPV-45 (1.42%), HPV-52 (0.71%), HPV-35 (2.14%) and HPV-39 (0.71%) of the 196 cases studied. It was also observed that in 69.73% of lesions single type genome was detected while in 30.52% cases there was mixed genotypes of HPV was seen. Different HPV types detected were HPV16, 33, 39, 45, 52 and 58 in Head & Neck carcinomas. There was no 100% co-relation of HPV as a sole etiological agent in the genesis of the squamous cell carcinoma. Oral cancers occurred typically in more than 50 yrs, chronic drinkers and smokers. Some studies suggest that 15% - 25% of the oropharyngeal cancers are associated with HPV-16. In cervical cancers apart from different types of HPV detected, it was also observed that in single patient multiple HPV types were found.
Authors and Affiliations
Parijath Goswami, Shashank Pandya, Shilpa Patel
Keywords
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