Human protamine 1 gene structure and function affected by rs35576928 mutation: a bioinformatics analysis

Abstract

Human sperm contain most type 1 and type 2 protamines (PRM1) and (PRM2), protamines, which have about equal proportions in normal sperm. Protamines can infertile if they change structure or function. Nucleotide polymorphisms are one cause of changes in protamine structure and function. For protamine 1 the genetic variation rs35576928 is known. In. this study bioinformatics approach was used to investigate the effects of the rs35576928 mutation on protamine 1 structure and function. matics tools including RNAsnp, NetGene2, in this study several bioinformatics tools were used to investigate how the polymorphism affects RNA structure and splicing. The tools used included RNAsnp, NetGene2, and ASAP. To evaluate the effects of rs35576928 on proteins, other tools such as SNAP and ExPASy were also used. The analyzes have also shown that this polymorphism has the primary, secondary and The results of this study have also shown that this polymorphism has primary, secondary, and the results of this study have also shown that this polymorphism has primary, secondary, and results of this study have also shown that protamine 1 has the following functions: general functions. Infertile males may be affected by rs35576928 as it has destructive effects on protamine RNA and protein structure.

Authors and Affiliations

Ramchandra Suthar; Elham Kazemi

Keywords

Related Articles

Medicinal plants as a hopeful therapeutic approach against COVID-19 infection

The disease of COVID-19 is generated by the SARS-COV-2 virus and principally attacks the lung tissue. In addition, other tissues are also attacked by the virus. Reports have shown that the clinical symptoms of this disea...

Vitamins and male infertility: role of various vitamins versus oxidative stress

Reactive oxygen species (ROS) are necessary for regular functions of spermatozoa including acrosome reaction, capacitation, fertilization, etc. But its high amount can be harmful to the function of the sperm cell. Compar...

Prostate cancer as a multifactorial disorder: an overview of the different sides of disease

Prostate cancer is the most common cancer in males and the second leading cause of death after lung cancer. Prostate tumors are sometimes benign, but malignant ones are clinically divided into two categories. The first g...

Supplementation of IVM culture media with GDF-9 can potentially enhance oocyte quality, fertilization and embryo development in ICSI procedure

In vitro maturation (IVM) of human oocytes is an important factor in assisted reproductive technology (ART) laboratories. The present study was aimed to investigate the effect of growth differentiation factor 9 (GDF-9) s...

Potential therapeutic effects of herbal drug resveratrol against cancer

Cancer is a major global problem that faces many therapeutic challenges. Drug resistance can be an important problem in cancer treatment with chemotherapy. The use of plant-based compounds that have anti-cancer propertie...

Download PDF file
  • EP ID EP714368
  • DOI 10.22034/CAJMPSI.2021.05.02
  • Views 72
  • Downloads 0

How To Cite

Ramchandra Suthar; Elham Kazemi (2021). Human protamine 1 gene structure and function affected by rs35576928 mutation: a bioinformatics analysis. Central Asian Journal of Medical and Pharmaceutical Sciences Innovation, 1(5), -. https://europub.co.uk/articles/-A-714368