HYDRALAZINE? ESSENTIAL OR HAS A POTENTIAL FOR COMPLICATIONS IN DERMATOLOGY
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2015, Vol 2, Issue 7
Abstract
: BACKGROUND: Hydralazine is a drug which is vasodilator, it lowers blood pressure and allows blood to flow more easily in veins and arteries. Hydralazine is used to treat hypertension. OBJECTIVES: The purpose of this prospective study is to determine role of – Hydralazine in dermatological complications. METHODS: In this descriptive, prospective, observational, cross sectional study, all patients who presented to the department of dermatology during this study period of 12 months from January 2010-December 2010 in. were included. RESULTS: Total number of males in the present study was 19(74%), females in the study was 6(26%). Mean age was 55.28±15.74 (SD) years, number of patients in the age group 31-40 years was 3(12%), 41-50 years was 5(20%), 51-60 years was 7(28%), number of patients in 61-70 years was 4(16%), number of patients in the age group 71-80 years was 4(16%), number of patients in the age group 71-80 years was 2(8%). Maximum number of patients was in their middle age between 41-60 years. Flushing was seen in 8(32%) patients, Urticarial rashes were seen in 10(40%) patients, Lupus-like syndrome was seen in 5(20%) patients, Hypersensitivity reactions was seen in 5(20%) patients, ANA-positivity was seen in 5(20%) patients, out of all the dermatological manifestations Urticarial rashes were seen in maximum number of patients i.e., in 10(40%) patients. Lupus-like syndrome was seen in 5(20%) patients all of whom belonged to the age group 31-60 years. Flushing was seen in 6 (31.57%) patients in males, Urticarial rashes were seen in 8(42.10%) male, lupus like syndrome was seen in 5(26.31%) males, hypersensitivity was seen in 4(21.05%) males and ANA positivity was seen in 5(26.31%) males. Flushing was seen in 2(33.33%) patients in females, Urticarial rashes were seen in 2(33.33%) females, hypersensitivity was seen in 1(16.66%) females and ANA positivity & lupus like syndrome was not seen in females. P value of all symptoms being insignificant. CONCLUSION: There is significant percentage of patients who report with dermatological manifestations with hydralazine in first 6months after initiation as an add on drug.
Authors and Affiliations
Satish K. S, Chanabasappa Mendagudli, Neelima Ravipati
Keywords
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- EP ID EP223158
- DOI 10.18410/jebmh/2015/112
- Views 117
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