Hydrochlorothiazide and Chlorthalidone Induced Hyponatremia – A Comparative Analysis for Concern
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 1
Abstract
Thiazide diuretics like hydrochlorothiazide (HCTZ) and chlorthalidone (CT) are commonly used pharmacological agents for the treatment of hypertension preferably in elderly patients. Previously we ignored risk of hyponatremia following diuretics therapy but much more attention paid to prevent hypokalemia. In this study we are giving more attention to the fact that hyponatremia is developed after the use of low dose of HCTZ & CT in hypertensive elderly patient. We reviewed the list of hypertensive patients hospitalized in Midnapore Medical College for hyponatremia from January 2015 to December 2015. We identified 40 (19M/21F) hypertensive patients (mean age 66±9.4yrs) hospitalized because of hyponatremia due to diuretics (HCTZ & CT). Twenty for each group (20HCTZ group & 20 CT group). Across all ages, the OR(Odds Ratio) for severe hyponatremia in HCTZ group vs CT group was 10.2 (95% CI: 1.12 -93.35).The OR for hyponatremia in patients of both Groups male vs female was insignificant. The OR for hyponatremia in patients of both sexes older than 65years vs those younger than 65 years was 1.5 (95% CI:0.84- 5.44). In this study we observed , all patients was received combined antihypertensive HCTZ with ARB or CCB , dose of HCTZ was 12.5mg and CT with ARB , dose of CT was 6.25mg. No dose variation was seen in diuretics.Elderly patients are likely to be at particularly high risk. In such cases diuretic use should be associated with close monitoring of sodium levels
Authors and Affiliations
Gantait K
Keywords
Related Articles
- EP ID EP246243
- DOI -
- Views 106
- Downloads 0
Joubert Syndrome: A Rare Cause for Developmental Delay
Joubert syndrome (JS) is a very rare autosomal recessive condition. It is a complex mid and hind brain malformations that resembles a molar tooth on axial MR scans. The importance of recognising JS is related to the outc...
Toxic And Histopathological Changes of harmful Effect of Diclofenac Sodium on Some Loose Organs in Albino Rats for Twelve Weeks
The present investigation demonstrated the side effect of (I.M.) injection (75 mg/3 ml/ rat/ week) of diclofenac sodium for 12 week on the histological structure of some loose organs of adult rats. During the study no cl...
Limberg Flap Repair: Our Experience
Background: There are numbers of surgical methods have been devised over a year for treatment of pilonidal sinus but none have been accepted as procedure of choice. Plastic reconstruction procedures have advantage of ear...
Comparison of the Performance of QF-PCR with QPCR as A Rapid Molecular-Based Method for Sex Chromosome Aneuploidies Detection
Objective: The high prevalence and variable phenotype of sex chromosome aneuploidies, necessitated the development of a robust method allowing their rapid prenatal diagnosis. Quantitative Fluorescent Polymerase Chain Rea...
Evaluation of Alvarado Scoring System in Preoperative Diagnosis of Acute Appendicitis
Background: Aim of the study was to evaluate Alvarado scoring system in preoperative diagnosis of Acute Appendicitis and to compare clinical diagnosis and Alvarado scoring for early diagnosis and correlate them with hist...