Hyperbasophilic Variant of Acute Promyelocytic Leukemia
Journal Title: MVP Journal of Medical Sciences - Year 2016, Vol 3, Issue 2
Abstract
Acute Promyelocytic Leukemia (APL) is an extremely rare variant of acute myeloid leukemia. APL constitutes around 10-15 % of acute myeloid leukemia in adults. It is commonly diagnosed around 40 years age. Molecular/genetic studies exhibit chromosomal translocation between chromosome 15 and chromosome 17-t(15;17)(q22;q21) and PML-RARa rearrangement. Four variants of APL have been identified: The classic form M3 hypergranular variant, the microgranular variant, the hyperbasophilic form and zinc-finger form-M3r, identified by a different chromosomal translocation, between chromosome 11 and chromosome 17:t(11,17) (q23, q11-12).
Authors and Affiliations
Preeti Bajaj, Rajyaguru Devangana, B. S. Shah, Amrinder Kaur
Keywords
Related Articles
- EP ID EP431022
- DOI 10.18311/mvpjms/2016/v3i2/7702
- Views 99
- Downloads 0
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