Hyperferritinemia in Dengue Fever-Correlation between Serum Ferritin and Thrombocytopenia

Journal Title: Journal of Clinical and Diagnostic Research - Year 2018, Vol 12, Issue 4

Abstract

ABSTRACT Introduction: Dengue fever is a widely prevalent viral infection in the tropical countries. Many patients with dengue fever are known to have severe cytopenias and the mechanism for the same is not known. Macrophage Activation Syndrome (MAS) is a life threatening complication that is known to be triggered by viral infections. This study attempts to examine the possibility of MAS as an underlying cause of cytopenias in dengue fever. Hyperferritinemia which is an important diagnostic criteria for MAS is known to occur in dengue fever also. Aim: The primary objective of the study was to assess the correlation between ferritin levels and mean platelet drop among patients admitted with dengue fever. Secondary objective was to do a subgroup analysis and compare the patients treated according to WHO standard protocols in dengue fever with those who were also given steroids and compare outcomes. Materials and Methods: This was a retrospective study done over a period of 18 months. Patients with dengue fever who satisfied the criteria for MAS were selected and the mean change in platelet count between the time of admission and 48 hours later was calculated. This was compared with the ferritin levels. Subgroup analysis was also done and the groups were correlated on two important clinical outcomes-the mean platelet drop and length of stay in hospital. Results: Total of 26 patients were enrolled in the study (n=26), of whom 18 (69.2%) were male. Pearson’s correlation coefficient (-0.231) was calculated to compare Ferritin levels with mean platelet drop and it showed that there was no correlation. There was no difference between the two groups with respect to mean platelet drop (p=0.08) and length of stay (p=0.443) in hospital. Conclusion: Hence, it can be concluded that hyperferritinemia does not correlate with the severity of platelet drop. There was no significant change in outcomes in patients with dengue fever associated MAS who were treated with steroids or with only standard treatment protocol.

Authors and Affiliations

S Jyothi Visalakshy, Selva Saravanan Saminathan, Sandeep Surendran, MGK Pillai

Keywords

Related Articles

Comparison of Central Corneal Thickness using Anterior Segment Optical Coherence Tomography Versus Ultrasound Pachymetry

Introduction: Corneal thickness is an important and sensitive indicator of corneal health. It is useful in monitoring corneal diseases such as corneal oedema and keratoconus, and selecting patients for refractive surgery...

Occupation Hazards – Pattern, Awareness and Preventive Measures among Welders from an Unorganized Sector in India

Introduction: Welding is an occupation associated with tremendous physical and chemical hazards. In spite of the risk involved, usage of Personal Protective Gears (PPGs) among welders in developing countries has been rep...

A Rare Case of Digoxin Associated Gingival Overgrowth

This case report presents a case of drug induced gingival overgrowth in a 28-year-old female patient with history of Coronary Artery Disease (CAD) and was prescribed digoxin in combination with furosemide and acitrom for...

Effect of Sodium Valproate and Docosahexaenoic Acid on Pain in Rats

Introduction: Analgesics are commonly prescribed medications used to alleviate pain of various aetiologies without affecting the patient’s consciousness. They interfere with the transmission of pain signals. A commonly u...

Download PDF file
  • EP ID EP522953
  • DOI 10.7860/JCDR/2018/34809.11403
  • Views 63
  • Downloads 0

How To Cite

S Jyothi Visalakshy, Selva Saravanan Saminathan, Sandeep Surendran, MGK Pillai (2018). Hyperferritinemia in Dengue Fever-Correlation between Serum Ferritin and Thrombocytopenia. Journal of Clinical and Diagnostic Research, 12(4), 7-9. https://europub.co.uk/articles/-A-522953