Hyperfractionated radiotherapy and concurrent chemotherapy in locally advanced hypopharyngeal cancers– an institutional experience
Journal Title: International Journal of Medical Research and Review - Year 2016, Vol 4, Issue 6
Abstract
Aim: To determine whether hyperfractionated radiotherapy with concurrent cisplatin improves outcome in advanced hypopharyngeal cancers. Methodology: From 2012 to 2014, twenty three patients diagnosed with squamous cell carcinoma of hypopharynx (Stg III-7, Stg IVA-14, and Stg IVB-2) were assigned to receive total dose of 75.9 Gy in 66 fractions @ 1.15 Gy/fraction, twice daily with inter-fraction interval of 6 hours, 5 days/week, over 45 days. Spinal cord shielding was done at 50.6 Gy in 44 fractions. Concurrent chemotherapy was delivered with cisplatin 40 mg/m2 once weekly. The tumor response was assessed at 6 weeks and 3 months after the completion of treatment. Results: All the recruited 23 patients completed the planned treatment. The complete response at 6 weeks and 3 months post treatment for primary and node was observed in 16/23 and 18/23, 13/23 and 16/23 patients respectively. The grade I and II toxicities encountered during the treatment were mucositis (16 patients), radiation dermatitis (20 patients), neutropenia (9 patients), and leucopenia (18 patients). Grade 3 reactions seen were mucositis (6 patients), neutropenia (3 patients), leucopenia (2 patients), skin (2 patients) and none of the patients had grade IV reactions. The nutrition was maintained with feeding nasogastric tubes and parentral infusion though out the treatment. The median follow up was 18 months with a median overall survival of 24 months and median disease free survival was 18 months without any statistical significance. Conclusion: Hyperfractionated radiotherapy combined with concurrent weekly cisplatin treatment for locally advanced hypopharyngeal cancers can be considered with rigorous monitoring and management of the toxicities.
Authors and Affiliations
Thejaswini B,, R Nanda, Aradhana K,, Ashalatha Ashalatha, G. V. Giri, Shamsundar, Shamsundar,
Keywords
Related Articles
- EP ID EP230301
- DOI 10.17511
- Views 116
- Downloads 0
Prevalence of hypertension and its risk factors among adults in central Kerala
Introduction: High blood pressure is both preventable and treatable. Community based studies on the prevalence of hypertension is now necessary to assess the prevalence of hypertension & its risk factors. Epidemiological...
Clinical study on efficacy of infliximab on severity and occurrence of acute anterior uveitis in HLA-B27
Aim: To study the efficacy of Infliximab on the severity and occurrence of Acute Anterior Uveitis in HLA B27 positive patients. Materials and Methods: This is a prospective observational study done on 30 patients with ac...
Study of new onset cutaneous manifestations in Rheumatic Diseases
Background: Skin manifestations are an important clue to underlying rheumatological conditions and at times the first manifestation of the disease. Their identification helps in diagnosis, classification and follow up of...
Effect of premolar extraction on Bolton overall ratio in north Indian population
Introduction: Bolton ratio is considered as seventh key of normal occlusion. Many orthodontic patients have to undergo premolar extractions as a part of treatment. Aims and objectives: The present study was taken up to i...
Father’s knowledge and attitude towards breast feeding
Introduction: A father’s knowledge and attitude towards breastfeeding are very important for the success of breastfeeding practices. There is no uniform practice of including them in the education sessions in our country...