Hyperglycosylated immunoglobulins of blood serum of patients with multiple sclerosis as a diagnostic and prognostic biomarker for this disease
Journal Title: Український неврологічний журнал - Year 2018, Vol 0, Issue 1
Abstract
Objective — to investigate the patterns of detection of hyperglycosylated immunoglobulins (Igs) in blood serum of patients with multiple sclerosis (MS) and to identify clinical features of this disease. Methods and subjects. 28 patients with MS and 12 healthy volunteers were involved into the study. Applied methods are clinical — analysis of complaints, history of disease and life, general and neurological examinations; laboratory — precipitation of blood serum proteins with 10 % trichloroacetic acid, electrophoresis of the examined blood serum proteins, analysis of the obtained electrophoregrams and their Western blotting for identificationof heavy and light chains of detected hyperglycosylated Igs. Results. Hyperglycosylation of Igs was revealed in 14.28 % of MS patients and it was not recorded in any one of the control group. Such Igs were detected in various types of MS (75 % in relapsingremitting MS and 25 % in secondary progressive MS). It was also present at different duration of the disease (from 1.5 to 20 years) and at varied levels of patients’ disability (from light to severe degree). Occurrence of hyperglycosylated antibodies was combined with the MS relapse. Conclusions. There is a definite clinical and immunological relationship between the presence of hyperglycosylated Igs in the blood serum of patients with MS and clinical features of the disease course. Detection of such Igs in MS patients can serve as a biomarker of the disease activity that is explained by an increase in the proinflammatory properties of the antibodies due to an increase in their glycosylation.
Authors and Affiliations
N. O. Negrych
Keywords
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