HYPERICUM PERFORATUM IMPROVE MEMORY AND LEARNING IN ALZHEIMER'S MODEL: (EXPERIMENTAL STUDY IN MICE)
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 8
Abstract
Objective: The aim of this study, we based on protective and antioxidant efficiency of Hypericum perforatum that shows a wide range of beneficial effect in vitro and in vivo.Methods: The in vitro antioxidant activity of the extract was assessed by using several antioxidant tests. The cytotoxic activity of Hypericum perforatum was also determined by using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide viability assay on ordinary used cell lines. In vivo experiments in Swiss mice were determined by performing behavioral, memory tests and histological study. According to tests results, H. perforatum may be relevant to the treatment of cognitive disorders.Results: The results of chemical analysis showed a hight level of hyperforin and quercitin that had an important antioxidant activity proved in vitro with the 2, 2-diphenyl-1-picrylhydrazyl, Anti-lactoperoxidase and superoxide dismutases; this antioxidant activity was confirmed in vivo after the non-toxic results by means of improvement in behavioral and memory than the reducing shrunken in pyramidal cells of mice brains.Conclusion: The present study suggests that Hypericum perforatum modulate the oxidative stress and be involved in the protective effect against oxidative damage and neurodegenerative diseases in mice.
Authors and Affiliations
Khayra Zerrouki, Noureddine Djebli, Esra Eroglu Ozkan, Nurten Ozsoy, Ozhan Gul, Afife Mat
Keywords
Related Articles
- EP ID EP576109
- DOI -
- Views 55
- Downloads 0
A COMPARATIVE PHARMACOGNOSTICAL EVALUATION OF THREE BOTANICAL SOURCE PLANTS OF JIVANTI
Objective: This study was undertaken to carry out a comparative pharmacognostical evaluation of three botanical source plants used in the name of classical Ayurvedic drug Jivanti.Methods: Leaves of three source plants of...
XANTHINE OXIDASE INHIBITORY AND ANTIHYPERURICEMIC ACTIVITIES OF ANREDERA CORDIFOLIA (TEN) STEENIS, SONCHUS ARVENSIS L, AND ITS COMBINATION
Objective: The objective of this research was to evaluate the xanthine oxidase (XO) inhibitory activity and the ability to reduce serum uric acid levels of 70% ethanol extracts of Anredera cordifolia (ACE) and Sonchus ar...
EVALUATION OF ANXIOLYTIC ACTIVITY OF METHANOL EXTRACT OF TRACHYSPERMUM AMMI L
Objective: The anxiolytic activity of the methanol extract of Trachyspermum ammi. L was investigated by hole board and passive avoidance response test.Methods: The study was conducted using hole board and passive avoidan...
A COMPREHENSIVE REVIEW ON ULCER HEALING POTENTIAL OF MEDICINAL PLANTS
Peptic ulcers are a broad term that includes ulcers of gastrointestinal tract. The formation of peptic ulcers is due to the presence of acid, peptic activity in gastric juice and a breakdown in mucosal defenses. There ar...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION OF GATIFLOXACIN AND AMBROXOL HCL IN PHARMACEUTICAL DOSAGE FORM
Objective: To develop a simple, selective, linear, precise and accurate RP-HPLC method for simultaneous estimation of Gatifloxacin and Ambroxol HCl in tablet dosage form.Methods: The chromatographic separation was perfor...