HYPERLIPIDEMIA IN DIABETIC AND HYPOTHYROID PATIENTS: CASE CONTROL STUDY
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2017, Vol 2, Issue 8
Abstract
BACKGROUND: Hyperlipidemia is the leading cause of death in the CVD patients. Diabetes and hypothyroidism are the two main endocrine risk factors for hyperlipidemia. Diabetes is associated with altered metabolism of triglyceride (TG) levels, LDL levels. Hypothyroidism leads to decreased clearance of TG and catabolism of LDL. METHODS: This was a case control study with 287 subjects that include normal population, diabetic and hypothyroid patients. The plasma lipid levels, thyroid prole, sugar levels are taken from the subjects. The data is subjected to unpaired t test for statistical analysis. The p value of <0.05 is indicative of statistical signicance. RESULTS: The 287 subjects are divided to 104 diabetic, 81 hypothyroid and 103 normal population. The hyperlipidemia cases found among them are 63, 26 and 32 in diabetics, hypothyroid patients and normal population respectively. The mean values of lipid levels in diabetic, thyroid and normal population are TC (211.4+4.24, 190.5+3.57mg/dl and 187.3+1.91mg/dl), LDL (134.5+3.01, 120.8+2.035 and 115.8+1.64mg/dl), TG (188.6+4.14, 169.9+0.74 and 163.2+2.42mg/dl) and HDL (39.64+0.45, 38.78+0.49 and 38.64+0.12mg/dl). The values obtained are statistically signicant. Lipid levels of diabetic and thyroid patients are found to be more than the normal population, of which diabetic patients show higher levels. The mean levels of TC, LDL, TG in diabetics and LDL, TG in hypothyroid patients were found to be more than the normal range. CONCLUSION: The secondary hyperlipidemia due to diabetes and thyroid can be manageable. Routine lipid prole monitoring in the patients with diabetes and thyroid disorders is advisable for the primary prevention of hyperlipidemia. Proper treatment of diabetes and hypothyroidism can prevent the hyperlipidemia.
Authors and Affiliations
Arun Koyyada
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