Hyperprolactinemia diagnostics – dilemmas over optimal selection of prolactinemia time points
Journal Title: Annals of Agricultural and Environmental Medicine - Year 2015, Vol 22, Issue 2
Abstract
Introduction. Laboratory discrimination of pathologic hyperprolactinemia is an important step in the diagnosis of pathology influencing overall health and fertility. A major issue is the choice of time and circumstances for obtaining a blood sample for prolactin assay that would be representative for mean daily plasma concentration of a subject. Objectives. The aim of the study was a comparison of reliability of single prolactin assessment on various time-points in a day with circadian prolactinemia profile in order to find the easiest, the least expensive, and the most reliable method of hyperprolactinemia diagnosis. Materials and method. The study was a retrospective analysis of 138 women, hospitalized in the Department of Endocrinology and Metabolic Diseases, Polish Mother`s Memorial Hospital – Research Institute, Lodz, Poland, in whom the circadian profile of prolactin (including assays at 8.00 am, 11.00 am, 2.00 pm, 5.00 pm, 8.00 pm, 11.00 pm, 2.00 am, 5.00 am and repeatedly at 8.00 am) had been assessed. Results. On the basis of AUC (area under the curve) of prolactin concentrations, hyperprolactinemia was diagnosed in 34 subjects (24.6 % of the entire group). The attempts to diagnose hyperprolactinemia based on a single prolactin assay failed due to a high percentage of false negative and false positive results. Only significant hyperprolactinemia with mean prolactin concentration of about 100 µg/l or more appeared easy to diagnose. Combinations of several time points also appeared not reliable enough. Conclusion. The nine-point daily profile of prolactinemia in any patient with clinical suspicion of hyperprolactinemia seems the best mode for estimating mean circadian prolactin concentration.
Authors and Affiliations
Konrad Szosland, Magdalena Stasiak, Andrzej Lewiński
Keywords
Related Articles
- EP ID EP80969
- DOI -
- Views 149
- Downloads 0
Estimation of physical activity and prevalence of excessive body mass in rural and urban Polish adolescents
Excessive body mass and sedentary lifestyle are well-known factors for cardiovascular risk, which when present in the young population may have significant health consequences, both in the short- and long-term. The aim o...
Immune and clinical response to honeybee venom in beekeepers
OBJECTIVE:The aim of the study was to assess immune response to honeybee venom in relation to the degree of exposure, time after a sting and clinical symptoms.MATERIALS AND METHOD:Fifty-four volunteers were divided into...
Application of the hypothesis of Developmental Origin of Health and Diseases (DOHaD) in epidemiological studies of women at reproductive age and pregnant women in Poland
Epidemiological population studies indicate that the nutrition of women at reproductive age and during pregnancy exerts an effect not only on the term of delivery, development of the foetus and birth weight, but also on...
Factors involved in the phenological mechanism of Alnus flowering in Central Europe.
The objectives of this paper are to ascertain the main factors involved in the phenological mechanism of alder flowering in Central Europe by understanding the influence of the main meteorological parameters, the North A...
Sublingual immunotherapy (SLIT) – indications, mechanism, and efficacy Position paper prepared by the Section of Immunotherapy, Polish Society of Allergy
SLIT ([i]sublingual immunotherapy[/i],) induces allergen-specific immune tolerance by sublingual administration of a gradually increasing dose of an allergen. The mechanism of SLIT is comparable to those during SCIT (sub...