Abstract

We report the case of a girl, with idiopathic Central Precocious Puberty (CPP), who experienced multiple episodes of erythematous rashes after the subcutaneous administration of Decapeptyl® (triptorelin). The allergological evaluation (including prick, intradermal and patch tests with the indicted drug and inhalant and food allergens) was negative. Considering that she needed to use GnRH analogs to treat CPP, a tolerance test with an alternative medication such as leuprolide acetate (Enantone®) was performed with an antihistamine coverage (cetirizine). The girl continued this treatment without side effects for 6 months, when experienced again a macula-papular exanthema. Given that triptorelin is the mainstay therapy for the CPP, we tested this medication prior cetirizine and betamethasone 1 mg, without problems, allowing her to easily manage her disease.

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