Hypoglycemic Activity of Curcuma longa LinnRoot Extracts on Alloxan Induced Diabetic Rats
Journal Title: Haya: The Saudi Journal of Life Sciences - Year 2017, Vol 2, Issue 2
Abstract
Abstract: Plants form the main ingredients of medicine in traditional system of healing and have been the source of inspiration for several major pharmaceutical drugs. In spite of great advances of modern scientific medicine, there is a rapid increase in the use of alternative medicine worldwide. To investigate the effect of the aqueous root extract, Methanol and n-Hexane root fractions of Curcuma longa Linnon Alloxan Induced Diabetic Rats. A total of thirty-six (36) rats were used and were grouped into six (6) groups of six (6) rats each. Group I served as normal control, group II served as diabetic control, Group III rats were induced with diabetes and administered with standard drug (Metformin, 100mg/kg) while Groups IV, V and VI were induced with diabetes and administered with crude aqueous extract, methanol and n-hexane fractions respectively at a dose of 400mg/kg body weight for four weeks. The research found that the methanol fraction showed highest potency with a significant (p<0.05) decrease in blood glucose level when compared to diabetic control after few days of fraction administration, it was followed by the aqueous extract which also shows hypoglycemic activity a week after administration. N-hexane fraction showed a marked hypoglycemic activity only after about two weeks of administration with the fraction. The present study demonstrated that the methanol fraction possesses the highest hypoglycemic activity. Keywords: Alloxan, Hypoglycemic activity, Curcuma longa linn and Metformin.
Authors and Affiliations
A. Mohammed, A. M. Wudil, A. J. Alhassan, A. A. Imam, I. U. Muhammad
Keywords
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