HYPOLIPIDEMIC EFFECT OF MORINGA OLEIFERA SEED OIL ON HIGH FAT-DIET INDUCED HYPERLIPIDEMIA IN LIVER AND HEART OF ALBINO RATS
Journal Title: Mintage journal of pharmaceutical and medical sciences - Year 2018, Vol 7, Issue 2
Abstract
Objective: This study investigated the effect of Moringa oleifera seed oil on High fat-diet induced hyperlipidemia in liver and heart of albino rats for a period of 10 days. Methods: Twenty-four albino male Wistar rats were divided into four experimental groups of six animals each. Group 1 were fed with normal diet, Group 2 were fed with high fat-diet while Group 3 were fed with high fat-diet + Moringa oleifera seed oil extract (2ml/kg bodyweight) and Group 4 were fed with high fat diet for 7days + Moringa oleifera seed oil extract (2ml/kg bodyweight) later days. Results: The result shows significant (p < 0.05) increase in Triglycerides level in liver and heart (139.2± 25.80 and 209.7± 7.65 mmol/l) of rat fed with High fat–diet relative to control (73.93± 6.63 and 58.85 ± 4.86 mmol/l). Treatment with Moringa seed oil shows a significant (p < 0.05) decrease in the heart Triglyceride levels and Total cholesterol levels (92.14±15.97 and 183.4±4.27 mmol/l) relative to high fat-diet rat (209.7±17.65 and 197.8±1.78 mmol/l). Rats fed with high fat-diet for 7 days before treatment with Moringa seed oil shows a significant (p < 0.05) decrease in liver and heart Triglyceride (75.55±5.94 and 104.9±9.95 mmol/l) when compared to High fat-diet rats (139.2±25.80 and 209.7±17.65 mmol/l). Histopathological changes induced by high fat-diet in liver of rats were also significantly ameliorated by the Moringa oleifera seed oil. Conclusion: This finding suggests that Moringa oleifera seed oil possess a hypolipidemic effect on high fat-diet induced hyperlipidemia in the liver and heart of albino rat.
Authors and Affiliations
OLATOSIN TEMITOPE MICHAEL TEMITOPE MICHAEL, OGUNBIYI, OLUWAGBENGA JOHN, MUSTAFA AFERAMOH MARYAM, APATA JOSEPH TOSIN
Keywords
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