Hypolipidemic effect of piper nigrum and zingiber officinale (mixed – extract) : An experimental study
Journal Title: INTERNATIONAL JOURNAL OF CURRENT RESEARCH - Year 2015, Vol 7, Issue 9
Abstract
The present study was planned to know the effect of mixed aqueous extract of piper nigrum & zingiberofficinale in high fat diet (HFD) induced hyperlipidemic albino rats. Phytochemical analysis was done separately on each aqueous extract. Alkaloids, saponins, tannins, phlobatanins, anthrax quinones, & cardenolides were found in both plants where as cardiac glycosides, steroids, &terpenoids were absent. Forty albino rats were randomly distributed into four groups (A-D) of ten albino rats each. All were fed with high fat diet (HFD) & water ad libitum. Group A was negative control group& Group D was positive control group and were not administered any extract. Whereas Group B & Group C were test groups, treated by mixed aqueous extract (P.Nigrum + Z.Officinale) at 400mg/kg.body weight & 800mg/kg.body weight respectively for forty-two days.The results showed that the treatment with mixed aqueous of ZO & PN at a dose of 800mg/kg body weight successfully reduced the elevated serum lipids more than the dose of 400mg/kg.body weight & that of simvastatin.These findings indicate that the mixed aqueous extract of ZO & PN can be used in hyperlipidaemia, a major cause of CVD. Thus, herbs PN & ZO may be useful in future as a leading compound for development of new drugs, after clinical trials.
Authors and Affiliations
Sunil Kharge, Dr. S. P. Dhonde, Dr. Nitin Nagane Dr. G. J. Belvalkar, Dr. P. E. Jagtap .
Keywords
Related Articles
- EP ID EP406020
- DOI -
- Views 126
- Downloads 0
Effect of structured teaching programme regarding first aid management among the school teachers at z. p.high school, piler, Andhra Pradesh, India
The aim of the present study was to assess the knowledge regarding first aid management among 30 Zilla Parishad High school teachers. In pre-test knowledge scores of teachers is Mean, 18.27 and Standard deviation 4.54403...
A comparative study on dimensions of organizational culture beteen top and middle Management of universitiesin Rajasthan
The eight values of organizational culture namely (openness, confrontation, trust, authenticity, pro-action, autonomy, collaboration and experimentation) were analyzed through t-test. The purpose of the present research...
Malaria in pregnancy: effect on maternal and fetal outcome in north-west rajasthan
Background & Objective: Malaria infection during pregnancy is a significant public health problem with substantial risks for the pregnant woman, her foetus, and the newborn child. So we conducted this study to predict th...
Non syndromic impacted Hyperdontic premolars: 2 case reports and review of literature
Tooth that is present in addition to the normal set of dentition was termed as supernumerary tooth or hyperdontia. They may be erupted or unerupted, single, multiple, unilateral or bilateral, and in one or both jaws. Mul...
Sensitization to mould aeroallergens in children with asthma and allergic rhinitis
Background: Approximately 80 fungus species have been reported to be connected with respiratory allergy. Moreover, it is proven that four of them are the most common: Alternaria, Cladosporium, Aspergillus, and Penicilliu...