Hypovitaminosis D is Associated with Gestational Diabetes Mellitus
Journal Title: Journal of Clinical and Diagnostic Research - Year 2017, Vol 11, Issue 10
Abstract
Introduction: Vitamin D deficiency has been shown to cause expression of insulin gene resulting in high insulin synthesis and secretion. It also decreases insulin resistance, thus affecting abnormal glucose metabolism and diabetes. Aim: To estimate total 25-hydroxy vitamin D levels in pregnant women and to find its association with Gestational Diabetes Mellitus (GDM). Materials and Methods: Fifty-four antenatal women were randomly enrolled at 24-28 weeks gestation after conforming to exclusion criteria. Serum vitamin D, two-hour 75 grams glucose and postprandial plasma glucose levels were estimated in all women at the time of enrollment. GDM was diagnosed with plasma glucose level >140 mg/dL (Group A). Rest of the women constituted Group B or control group. They were followed up till delivery. Vitamin D status and fetomaternal outcome was evaluated. Results: Hypovitaminosis D was found in 93% of women. There were 38.8% women (n=21) in GDM group compared to 61.2% (n=33) in control group. Vitamin D was significantly low in Group A than B (p-value 0.004). None of the women in Group A had vitamin D levels of 10 ng/mL and above compared to 37.2% in Group B. Severe vitamin D deficient women (levels <5 ng/ mL) had a risk ratio of 5.647 for developing GDM. A negative correlation was observed between vitamin D levels and plasma glucose levels. Conclusion: Hypovitaminosis D was associated with development of GDM.
Authors and Affiliations
Arijit Debnath, Mamta Gupta, Sanjay Jain, Supriya Kumari, Tamoghna Biswas, Somosri Ray, Santosh Kumar Gupta
Keywords
Related Articles
- EP ID EP364938
- DOI 10.7860/JCDR/2017/27433.10691
- Views 60
- Downloads 0
Internal Jugular Vein Thrombosis Mimicking Sternoclavicular Joint Septic Arthritis- A Rare Case Report
ABSTRACT Internal jugular vein thrombosis is a vascular disease occurring spontaneously. Some of the predisposing factors include trauma, intravenous catheterization and deep neck infections. It is important to an orthop...
Comparison of Central Corneal Thickness using Anterior Segment Optical Coherence Tomography Versus Ultrasound Pachymetry
Introduction: Corneal thickness is an important and sensitive indicator of corneal health. It is useful in monitoring corneal diseases such as corneal oedema and keratoconus, and selecting patients for refractive surgery...
Anatomical Study of Left Coronary Artery and its Variations–Cadaveric Study
ABSTRACT Introduction: Variations of the anatomy of the Coronary arteries are quiet common and have been reported previously in the literature. Right and Left coronary arteries which supply blood to the heart originates...
Relation between Chromium, Iron and Copper with Gestational Diabetes in Zabol, Iran
ABSTRACT Introduction: Diabetes is one of the most common chronic diseases. Gestational Diabetes Mellitus (GDM) is a type of diabetes that starts during pregnancy. Aim: To study the levels of chromium, iron, and copper i...
Adenomatoid Tumours: A Short Series with Literature Review
Adenomatoid tumours are hormone independent tumours of mesothelial origin. These are distinctive benign neoplasms usually localised in the epididymis in males and myometrium in females. They are uncommon and account for...