Identification of an Iranian family with Rh null phenotype
Journal Title: Khoon - Year 2018, Vol 15, Issue 1
Abstract
Identification of an Iranian family with Rh null phenotype Sabzikar E.1,2, Baghernejad Nashl A.1,2, Hasani F.1, Kiani A.A.1,2, Alijani S.1,2, Nezami M.1,2 Emami Fard M.1,2 1Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine, Tehran, Iran 2Qazvin Regional Blood Transfusion Center, Qazvin, Iran Abstract Background and Objectives Rh blood group system is one of the complex systems of blood groups and composed of nearly 50 antigens. The two gens of Rh D and Rh CE are responsible for coding of Rh system. Rh null genotype does not express any of these antigens. The prevalence of phenotype Rh null is 1 person per every 6×106 individuals and it is rather difficult to find compatible blood for the recipients in need. However, as there are probably members with similar characteristics in a given family, it would be plausible to diagnose the phenotype in family members to prepare compatible blood in time of need. Case In 2014, a 39-year-old negative female patient with hemolytic anemia referred to BoAli Hospital in Qazvin. Her sample, due to incompatibility in cross matching was further tested and her Rh null group was determined. Conclusions This case was identified by antibody screening tests and the subsequent determination of Rh antigen phenotype. After checking other family members, her brother was identified as the second Rh null group case in the country. Key words: Blood Transfusion, Phenotype, Antigen, Iran Received: 17 Aug 2015 Accepted: 3 Feb 2018 Correspondence: Sabzikar E., MSc of Hematology & Blood Banking. Blood Transfusion Research Center, High Institute for Research and Education in Transfusion Medicine and Qazvin Regional Blood Transfusion Center. Postal Code: 3416613445, Qazvin, Iran. Tel: (+9828) 12246727; Fax: (+9828) 12220136 E-mail: sabzikar.seven1986@yahoo.com
Authors and Affiliations
E. Sabzikar, A. Baghernejad Nashl, F. Hasani, A. A. Kiani, S. Alijani, M. Nezami
Keywords
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