IDENTIFICATION OF BENr GENE FROM CANDIDA ALBICANS IN SPUTUM SAMPLES
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 37
Abstract
BACKGROUND Candidiasis is caused by infection with species of the genus Candida, predominantly with Candida albicans. The growing problem of mucosal and systemic candidiasis reflects the enormous increase in the number of patients at risk and the increased opportunity that exists for Candida species to invade tissues that are normally resistant to invasion with the help of the Candida virulence markers such as adhesin, Germ tube, Pseudohyphae, slime production, exoenzymes etc. The respiratory tract is frequently colonized with Candida species, especially in hospitalised patients. The drug resistance shown by Candida is increasing day-by-day. The most common gene responsible for multi-drug resistance was noted as BENr. MATERIALS AND METHODS Candida albicans was isolated from the sputum by conventional methods. Antifungal susceptibility testing was done, and multidrug-resistant strains were subjected to genotyping to identify BENr gene by multiplex PCR. RESULTS From a total of 561 Candida albicans strains, 68 of them were multi-drug resistant and four strains have BENr gene. CONCLUSION BENr gene, which is responsible for multidrug resistance in Candida was present in our region.
Authors and Affiliations
Prasobh Krishnan Karukappillil, Riyaz Sherif, Lakshmi Sarayu, Simi Simi
Keywords
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- EP ID EP548007
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