Identification of immune hemolytic transfusion reaction and exploration of transfusion compatibility testing
Journal Title: Chinese Journal of Blood Transfusion - Year 2023, Vol 36, Issue 11
Abstract
Objective To analyze the causes of immune hemolytic transfusion reaction in one case, identify related antibodies, and explore transfusion compatibility testing. Methods ABO/Rh blood group identification, unexpected antibody identification of serum and diffusion fluid, direct antiglobulin test(DAT) and cross matching were conducted by saline method and/or microcolumn gel method. Results The patient′s blood group was O, and Rh phenotype was identified as DCCee. The DAT was negative, with strong anti-E antibody and weak anti-c antibody detected. Acute hemolytic transfusion reaction occurred in the patient after the last transfusion. Conclusion Currently, immune hemolytic transfusion reaction in China are mainly caused by Rh blood group system antibodies. The absence of unexpected antibody screening before blood transfusion and the weak anti-c antibody which resulted in missed detection of non compatibility in cross matching led to acute hemolytic transfusion reaction. It is recommended to conduct unexpected antibody screening before blood transfusion, and to collect blood sample for testing as soon as possible to improve the accuracy of DAT when acute hemolytic transfusion reaction is suspected.
Authors and Affiliations
Xiujuan JIAO, Zhuan LIU, Hongliang HUANG
Keywords
Related Articles
- EP ID EP738703
- DOI 10.13303/j.cjbt.issn.1004-549x.2023.11.023
- Views 42
- Downloads 0
Progress in immune hemolytic anemia caused by drugs
Drug-induced immune hemolytic anemia (DIIHA) is a rare cytopenia caused by damage to RBCs by drug-induced antibodies or non-immune protein adsorption (NIPA). The drugs associated with DIIHA and the mechanistic hypotheses...
Changes in perioperative blood group antibody of 33 type-A/B recipients in ABO-incompatible kidney transplantation
Objective To statistically analyze the perioperative results of patients with ABO-incompatible kidney transplantation (ABOi-KT), in order to explore the changes in blood group antibody of type-A/B recipients. Methods A t...
Efficacy of autologous ozoneized blood transfusion in improving motor function in convalescent stroke patients
Objective To investigate the efficacy of autologous ozoneized blood transfusion(AOBT) in improving consciousness and motor function in convalescent stroke patients. Methods A total of 44 patients who were diagnosed as co...
Perioperative blood management of a patient with coagulation factor Ⅴ deficiency and literature review
Objective To explore the perioperative blood management in patients with pancreatic pseudocyst combiend with coagulation factor Ⅴ(FⅤ) deficiency. Methods Preoperative: In order to determine the effect of cryoprecipitated...
Research progress of platelets and their derivatives based drug delivery systems
Platelets play an important role in physiological and pathological activities such as thrombosis, inflammation and tumorigenesis. At present, the application of platelets in drug delivery systems is increasingly studied....