Identification of Micro-RNA Seed Sequences and Other Possible Conserved Motifs: An Information Theoretic Approach
Journal Title: Journal of RNA and Genomics - Year 2017, Vol 13, Issue 1
Abstract
Micro-RNA (miRNA) is a small non-coding RNA molecule (22 nucleotides) found in plants, animals and some viruses, which regulates the expression of protein coding genes (target gene) by degrading or repressing the translation of its mRNA. For the regulation of target gene, in some cases micro RNA binds fully with mRNA, whereas in other cases it binds only through a specific conserved region in it, called the seed. These seeds having very specific location and size comprise of highly conserved nucleotide sequences. In this paper we have used a unsupervised computational technique to find out those seeds without using the biology of micro-RNA. Our method successfully managed to find 252 known seeds and also suggested a set of probable candidate for other conserved sequence, which can be used as a template for experiment.
Authors and Affiliations
Md Izhar Ashraf, Anny Leema A.
Keywords
Related Articles
- EP ID EP301975
- DOI -
- Views 46
- Downloads 0
Intramyocardial Gene Silencing by Interfering RNA
RNAi is a widely used methodology for gene silencing. The action mechanism of siRNA molecules has been well studied in recent years, and the technique has been optimized in terms of safety and effectiveness. Cardiovascul...
The Potential Link between Mobile DNA and the Invasiveness of the Species
The environment and its stressors have an effect on the genome structure of species, affecting their adaptation and evolution. Environmental stresses significantly increase the genetic variability of a population and thu...
Rethinking Delivery: Viral Vectors and RNA Interference
Efficient delivery of nucleic acids to their intended target cells remains the major complication holding back the widespread adoption of RNA interference (RNAi) therapies. In recent years, substantial progress has been...
piRNAs: the "Bodyguards" of Fertility
Among the small non coding RNAs classes, piRNAs are of particular interest because of their role in allowing the normal reproduction of individuals, from Drosophila to mouse. The reduction of piRNAs in the germ cells is...
Forgotten Circadian Aspect in miRNAs Oriented Research
Until today several tens of classes of small non-coding RNAs have been discovered. Among them a class of miRNAs represents one of the most abundant (and still growing) groups with thousands of members. miRNAs are express...