Identification of predictive marker of prerenal damage in pregnant women with Preeclampsia and women at high risk- A Prospective study conducted in Riyadh,Saudi Arabia
Journal Title: International Journal of Medical Science and Public Health - Year 2014, Vol 3, Issue 2
Abstract
Background: Preeclampsia is characterized by development of high blood pressure and proteinuria. It affects 5 – 8% of all pregnancies and is a major contributor to maternal and fetal morbidity and mortality. There is no single test that fulfils all the criteria for a good predictor of preeclampsia and associated renal damage. Aims & Objective s : To evaluate the role of serum and urine biochemical parameters as early predictors of preeclampsia . T o investigate the role of BUN: Creatinine ratio in diagnosing preeclampsia and evaluating prognosis of the disease. Material and Methods: In the present prospective study, one hundred and twenty pregnant women divided into three groups: normotensive (con trol), women at high risk and with preeclampsia were included. Analyses of different biochemical parameters including BUN: Creatinine were carried out. Results: There was significant difference in the mean value of serum uric acid, blood urea nitrogen, creatinine, urinary protein and B UN: Creatinine ratio in preeclampsia group compared to control group (p < 0.001). There was significant difference (p < 0.05) in se rum uric acid between control and preeclampsia group. However, there was no significant change in haematocrit , serum creatinine and urine protein between control and high risk group. Conclusion: BUN: Creatinine ratio in pregnant women with preeclampsia and also in high risk group was significantly increased (t = 15.55, p < 0.001 and t = 8.66, p < 0.001 respectively) in comparison to the control group. This index could be useful in eval uating the severity of preeclampsia and could be used as a predictor in p rognosis of preeclampsia and subsequent early renal disease
Authors and Affiliations
Noura Al - Jamei, Hajera Tabassum, Huda Al - Mayouf, Latifa Al - Otay, Amal Ali Al - Shenefy, Farah Khan
Keywords
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