Identyfikacja wirusów ludzkich brodawczaków (HPV) w stanach zapalnych i nowotworach uszu
Journal Title: Otolaryngologia Polska - Year 2007, Vol 61, Issue 2
Abstract
Introduction. Human Papilloma Virus has a strong relation to oropharyngeal mucosa and is considered to be responsible for a wide range of upper respiratory tract pathologies, like laryngeal papilloma. There’s a hypothesis, that it plays a significant role in middle ear chronic inflammations and neoplasm’s. Material and methodic. The examination was carried on a group of 53 patients, 39 of which was suffering from granulation tissue chronic otitis media, 7-cholesteatomatous otitis media, 6 – middle ear malignant neoplasm, and 1 middle and/or external ear benign neoplasm. The control group consistedof 5 patients operated on: otosclerosis – 4 cases and post-traumatic tympanic membrane perforation – 1 case. The material was postoperative tissue, like polyps, inflammatory granulation tissue, cholesteatoma masses and malignant neoplasm’s tissue. Results. In the whole group of 53 examined cases, HPV DNA was confirmed in 22 cases (41,5%), in that group oncogenic types 16 or 18 in 12 cases (22,6%), and in 14 cases (26,4%) types 6 or 11. In a group of chronic granulomatous otitis media DNA characteristic for Papilloma was identified in 12 cases (25,6%), in it in 9 cases DNA HPV type6 or 11 was confirmed, and in 7 cases type 16 or 18. Among cholesteatomatous chronic otitis media HPV DNA types 6 or 11 was identified in 70%. In every case of middle ear malignant neoplasm a presence of high-risk DNA Papilloma types 16 or 18 was confirmed. In any case of control group HPV DNA was detected. Conclusions. The results has been compared with other authors examinations and it is claimed that they confirm the observation, that Human Papilloma Viruses may be a factor, that might play an important role in pathology of chronic otitis media and ear neoplasm’s. It is concluded, thatdifferences in percentages of HPV presence in chronic inflammations (70%) and ear neoplasm’s may be explained by viral co-infection during bacterial c. o. m. Viral infection probably evolves carcinogenesis, which leads to a neoplastic growth.
Authors and Affiliations
Bogdan Rydzewski, Anna Goździcka-Józefiak, Jerzy Sokalski, Monika Matusiak, Łukasz Durzyński
Keywords
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