IFN-γ A/T Alleles Frequency Among Anti Toxoplasma IgG Seropositive and Seronegative Pregnant Women
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 2
Abstract
Background: Toxoplasma gondii is an obligate intracellular opportunistic protozoan parasite that can infect different vertebrate hosts including humans. Cell mediated immunity has a crucial role in the evolution of toxoplasmosis disease. TH1 cytokines and particularly, IFN-γ plays an important role in resistance to toxoplasmosis. Cytokines genes polymorphisms have been shown an association with susceptibility to parasitic diseases. Objective: the aim of this study was to detect the frequency in the gene encoding IFN-γ (+874T/A) among Toxoplasma gondii seropositive and seronegative pregnant women. Methods: This study was included 94 pregnant women divided into two groups: anti T. gondii IgG seropositive group 44(46%) and anti T. gondii IgG sero-negative group 50(54%). Presence and absence of IFN-γ A, and T alleles were detected by PCR using specific primers. Results: The differences between A and T alleles distributions were not statistically significant between the seropositive and seronegative pregnant women p value (>0.05), whereas T allele was slightly increased among seronegative group. Conclusion: a seropositive pregnant women that carrying a single A genotype could be associated with a high risk of infection reactivation against T. gondii.
Authors and Affiliations
Abdelhaleem A A
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