IgA nephropathy. Causes, symptoms and modern diagnostics of the most common glomerulonephritis
Journal Title: Postępy Nauk Medycznych - Year 2015, Vol 28, Issue 10
Abstract
IgA nephropathy (IgAN) is the most common glomerulonephritis. Its causes are notfully understood and can be divided into genetic, environmental and infectious. The spectraof histopathologic and clinical course of IgAN are highly variable. Most patients remainasymptomatic for a long period of time and the first symptoms such as proteinuria, haematuria,and hypertension are not specific to IgAN. We do not know the definitive prognosticfactors, so that we could precisely determine the IgAN progression, and consequently therisk of developing chronic and end-stage renal failure. Despite the knowledge progress,sensitive and specific diagnostic methods are still lacking. Although today renal biopsyremains the “gold standard” in the diagnosis of IgAN, the immunological, genetic, andproteomic diagnostics become more and more important. The proteomic analysis of proteinsof low molecular weight made possible to carry out a differential diagnosis betweenhealthy subjects and IgAN patients in remission of the disease, even in the absence ofpathological proteinuria. Perhaps in the future it will be possible to develop the whole mapof proteins to monitor different treatment regimens in IgAN.
Authors and Affiliations
Michał Florczak, Bartosz Foroncewicz, Leszek Pączek, Krzysztof Mucha
Keywords
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