Rapid identification system of frontal dysfunction in subclinical hepatic encephalopathy

Introduction and aim. Liver disease is associated with cognitive dysfunction also at early stages, and minimal hepatic encephalopathy, affecting 20-70% of patients, is frequently under-recognized. The main purpose of th...

Association of plasma visfatin with hepatic and systemicinflammation in nonalcoholic fatty liver disease

Background. Visfatin is a proinflammatory and insulin-mimetic adipokine contributing to whole body glucose and lipid metabolism. Studies to date are conflicting regarding the relationship between visfatin and non-alcohol...

Sofosbuvir-Based Therapy in the Pre-Liver Transplant Setting: The Canadian National Experience

Introduction and aim. Sofosbuvir (SOF)-based regimen has been shown to have high efficacy even in patients with decompensated cirrhosis. Treated patients may experience various degrees of hepatic recovery ranging from st...

MELD exception for liver transplantation in portopulmonary hypertension: current implementation and future considerations

G308A polymorphism of TNF-alpha gene is associated with insulin resistance and histological changes in non alcoholic fatty liver disease patien

Some studies have pointed to a role of TNF-alpha in pathogenesis of non alcoholic fatty liver disease (NAFLD). The aim of our study was to investigate the influence of G308A polymorphism TNF alpha gene on the histologica...