IL-1 Gene Cluster Polymorphisms in the Macedonian Population
Journal Title: Macedonian Journal of Medical Sciences (MJMS) - Year 2008, Vol 1, Issue 1
Abstract
The aim of this study was to genotype IL-1 gene cluster polymorphisms in the Macedonian population. A group composed of 301 healthy unrelated individuals was selected. IL-1 genotyping of the samples was performed by the PCR-SSP procedure followed by analysis of the IL-1 data with the PyPop population genetic analysis software package. The frequency of IL-1 alleles varies from 0.814 for IL1A -889/C, 0.729 for IL-1B +3962/C, 0.698 for IL-1RN mspa 11100/T, 0.671 for IL-1B -511/C, followed by 0.663 for IL-1R psti 1970/C indicating common “wild type†allele. We determined 27 different haplotypes from the total number of 32. The most frequent haplotypes for IL-1 are CCCCT (0.191), CTCCT (0.127), CCCTT (0.098), CCCCC (0.085), CTCTT (0.082). All pairs of loci for IL-1, except for IL-1R psti 1970, are in linkage disequilibrium, with p<0.05. The closest genetic distance is observed between the studied Macedonian population and the population from ItalyTorino, while the most genetically distant populations were TaiwanTsou, and TaiwanYami. It is concluded that IL-1 cluster alleles, genotypes, and haplotypes in Macedonian population show a good concordance with Hardy Weinberg equilibrium and can be used for anthropological comparisons, as well as for association studies with different diseases.
Authors and Affiliations
Dejan Trajkov| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “St. Kiril and Metodij”, Skopje, Republic of MacedoniaFrance, Aleksandar Petlichkovski| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “St. Kiril and Metodij”, Skopje, Republic of MacedoniaFrance, Ana Strezova| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “St. Kiril and Metodij”, Skopje, Republic of MacedoniaFrance, Slavica Hristomanova| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “St. Kiril and Metodij”, Skopje, Republic of MacedoniaFrance, Eli Djulejic| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “St. Kiril and Metodij”, Skopje, Republic of MacedoniaFrance, Jordan Petrov| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “St. Kiril and Metodij”, Skopje, Republic of MacedoniaFrance, Mirko Spiroski| Institute of Immunobiology and Human Genetics, Faculty of Medicine, University “St. Kiril and Metodij”, Skopje, Republic of MacedoniaFrance, Aneta Atanasovska-Stojanovska| Dental Clinical Center, Department of Oral Pathology and Periodontology, Faculty of Stomatology, University “Ss. Kiril and Metodij”, Skopje, Republic of Macedonia France, Jean Gogusev| INSERM U507, Hôpital Necker-Enfants Malades, Paris, France
Keywords
Related Articles
- EP ID EP8583
- DOI 10.3889/MJMS.1857-5773.2008.0001
- Views 497
- Downloads 25
Understanding the Role of General Dentists in the Process of Screening and Early Diagnosis of Oral Premalignant And Malignant Lesions - Brief Literature Review
Aim: To indicate about the need for involving general dentists in the process of screening and early detection of malignant and premalignant lesions. To make brief literature review, which lesions are included under th...
Contribution of Maternal Demographic and Medical Factors to the Risk of Prematurity in Qom Hospitals
Background. Prematurity remains the most significant cause of neonatal morbidity and mortality. Knowing which group of women is at risk for developing preterm labor will define a Target population for better prenatal c...
Risks and Complications in Aesthetic and Functional Septorhinoplasty
Background: Rhinoseptoplasty (RSP) is regarded to be associated with many risks. The expectations of patient and physician are not always corresponding. Besides of postoperative deformities many other risks and complic...
Effects of the Pharmacological Pre-treatment and Global Brain Ischemia on the Body Temperature in Experimental Rats
The aim of this study is to examine the influence of the pharmacologic pre-treatment and global brain ischemia on the one hand, and on the other hand, the influence of anaesthesia on the body temperature in experimenta...
Occurrence and Progression of Coronary Artery Disease in Patients with Type 2 Diabetes
Aim. The aims of reaserch project were to determine the predictive role of diabetes type 2 as independent factor and/or in correlation with others in occurrence, extent and prognosis of CAD, as well as to evaluate the...