IL-1Β POLYMORPHISMS AND ITS INTERACTION WITH NRG-1 ON THE RISK OF INTELLECTUAL DISABILITY
Journal Title: INTERNATIONAL JOURNAL OF PURE MEDICAL RESEARCH - Year 2017, Vol 2, Issue 5
Abstract
Trophic factors and cytokines are involved in neural development and regulate neurotransmission. In particular, interleukin-1β (IL-1β) and neuregulin-1 (NRG-1)have been recognized to play a key role in activity-dependent maturation and plasticity of excitatory synaptic structure and function. Genetic functional dysregulations of these molecules could impair neuronal processes inuencing cognitive development and may have a wide range of neurological consequences. Here we studied the impact ofIL-1β rs16944(- 511 T>C), rs1143634(+3962 C>T ), NRG-1rs6994992, NRG- 1rs35753505 and ErbB4 rs7598440 polymorphisms on the risk of cognitive impairment in children affected by mild/moderate intellectual disability (ID). Our ndings indicate that both the IL-1β variants are associated to ID. Moreover, analysis of gene-gene interaction suggests that there is an interaction between IL-1β and NRG-1 in ID risk. Measuring IL- 1β levels we evidenced higher IL-1β serum concentration in ID patients than in controls.
Authors and Affiliations
Dr. Anna Aureli, Mr. Pierluigi Sebastiani, Mrs. Tiziana Del Beato, Dr. Alessia Colanardi, Dr. Marta Grannonico, Dr. Enzo Sechi, Dr. Silvia Di Loreto
Keywords
Related Articles
- EP ID EP597519
- DOI -
- Views 66
- Downloads 0
AGGRESSIVE FIBROMATOSIS OF THE NECK AND MANDIBLE; REPORT OF TWO CHALLENGING CASES
We present our experience of two cases of rare connective tissue disease occurring within the midface. First case represented a very large painless slowly growing neck mass extending from mid neck to the clavicle displac...
IMMUNOHISTOCHEMICAL STUDY OF THE HUMAN PLACENTAL VASCULATURE AFTER NORMAL VAGINAL DELIVERY AND ELECTIVE CESEAREAN SECTION
The placenta is a temporary organ required for the development of embryo and fetus. It allows the physiological exchange between the fetus and the mother. Endothelin is a human protein has three isoforms, endothelin-1, -...
INCIDENCE AND OUTCOME OF CONGENITAL HEART DISEASE AMONG NEONATES WITH RESPIRATORY DISTRESS IN BENHA CHILDREN HOSPITAL NEONATAL INTENSIVE CARE UNIT
Background: Congenital Heart disease (CHD) is one of the most frequently occurring congenital defects which affect the newborn population. Congenital heart defects are very serious problem in current perinatology. The in...
EVALUATION OF CONTROL OF DIABETES MELLITUS IN HEMODIALYSIS PATIENTS: PERSPECTIVE STUDY
Management of diabetes includes many areas that may be inuenced by the severity of a patient's kidney dysfunction. This includes the methods that are used to determine the adequacy of diabetes control, such as hemoglobi...
THE DIVERGING EFFECTS OF ERYTHROPOIETIN AND U-74389G ON Γ-GLUTAMYL TRANSFERASE LEVELS
AIM: This study calculated the effects on gamma-glutamyltransferase (γgt) levels, after treatment with either of 2 drugs: the erythropoietin (Epo) and the antioxidant lazaroid (L) drug U-74389G. The calculation was based...