IL-4 and IL-6 in Bronchial Asthma Does IL-6 Plays More Important Role than IL-4? A Preliminary Study
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Summary: Cytokines IL-4, 5, 6 and 13 plays an important role in the pathogenesis & chronicity of bronchial Asthma. Main purpose of the study was to see role of IL-4 & IL-6 in allergic disease. Material & Method: Total 58 cases of bronchial asthma in which 10 cases were having allergic rhinitis and 07 had urticaria, along with 20 healthy controls were taken for study between period of November 13 to December 14. Result: Among 58 patients of asthma, 10 had associated rhinitis and 07 cases had urticaria. Out of 58 cases 58.62% patients were male and 41.38% patients were females. Total 13 patients were children of age group 3-15 year in which males were 23.53% & females were 20.83% . Most common age group was 16-30 years in which 54.16 % were female and 47.05% were male. Total 42 cases (72.41%) were between 3 to 30 years. IL-4 was raised significantly in asthma cases in 25% cases. Similarly, IL-6 was significantly elevated in 48.27% patients of asthma. Thus our study concludes that IL-6 plays more role in pathogenesis of asthma than IL-4. Monoclonal antibody to IL-6 may be tried on this cases`
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Prof Usha
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