iMAF - Index of Major Allele Frequency
Journal Title: Genetics & Applications - Year 2018, Vol 2, Issue 2
Abstract
Allele frequency is the relative frequency of an allele at a particular locus in a population (Gillespie et al., 2004). It is the basis of all population genetic analyses. Two parameters of allelic frequencies are special indicators: the major allele frequency when it comes to STR loci and the minor allele frequency when it comes to SNPs and other biallelic loci. The fluctuations of allele frequencies within and among populations have evolutionary significance, where selective pressure seeks to eliminate deleterious alleles, by favoring new genetic variants which bring an adaptive advantage. These effects of selection can directly modify major and minor allele frequencies by affecting the allele’s distribution. In the cases of adaptively neutral loci, genetic drift has a significant role on the distribution of allelic frequencies.
Authors and Affiliations
Naris Pojskić
Keywords
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- EP ID EP520805
- DOI 10.31383/ga.vol2iss2pp78-81
- Views 98
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iMAF - Index of Major Allele Frequency
Allele frequency is the relative frequency of an allele at a particular locus in a population (Gillespie et al., 2004). It is the basis of all population genetic analyses. Two parameters of allelic frequencies are specia...
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