Immobilization-induced increases of systolic blood pressure and dysregulation of electrolyte balance in ethanol-treated rats
Journal Title: Pakistan Journal of Pharmaceutical Sciences - Year 2015, Vol 28, Issue 4
Abstract
Clinical and experimental studies revealed that alcohol drinking and life event stresses are predisposing factors to hypertension. Intra and extra cellular levels of electrolytes may play important role in the pathogenesis and treatment of hypertension. Dietary intake of sodium, potassium, calcium and magnesium is suggested to have a role in the regulation of blood pressure. The present study was designed to monitor the effects of acute exposure to 2h immobilization stress and ethanol administration at a dose of 2.5g/kg body weight (i.p.) and combined effect of acute administration of ethanol and immobilization stress on systolic blood pressure (SBP), intraerythrocyte, serum and tissue electrolytes in rats. Results showed that acute exposure to 2h immobilization increased SBP, intraerythrocyte sodium and decreased intraerythrocyte potassium in water as well as in ethanol injected rats. The concentration of Na+ and Ca2+ increased while that of K+ and Mg2+ decreased in the heart and kidney tissue. Ethanol administration also increased Na+ and Ca2+levelsand decreased K+ and Mg2+ levels in the heart and kidney tissue. Restraint stress decreased serum levels of Na+, K+, Ca2+, P, and Cl – and increased serum Mg2+, glucose and haematocrit. Ethanol administration also decreased serum levels of Na+, K+, Ca2+, P, and Cl – and increased serum Mg2+, glucose and haematocrit. The effects of ethanol and stress on the changes of blood and tissues electrolytes were additive and may be involved in the greater occurrence of hypertension in alcoholics. Our results suggested an important role of intra and extra cellular electrolytes in both stress and ethanol-induced hypertension. The findings may help to develop strategies for the treatment of hypertension in alcoholics.
Authors and Affiliations
Farzana Yasmin , Zeba Haque , Huma Ikram , Darakhshan Jabeen Haleem
Keywords
Related Articles
- EP ID EP148369
- DOI -
- Views 101
- Downloads 0
Emergence of resistance to fluoroquinolones among gram positive and gram negative clinical isolates
Fluoroquinolones are broad-spectrum antibiotics that are considered as first line drugs to treat infectious diseases. In order to find out useful fluoroquinolones, the antibiotic resistance of fluoroquinolones, namely, o...
Bone Marrow Stromal Cell (BMSC) and skeletal aging: Role of telomerase enzyme
Abstract: Telomere shortening and telomerase deficiency have been linked with several age related degenerative diseases. Moreover, degenerative changes in various tissues/organs have been attributed to derangement...
Analysis of Insect toxicity and repellent activity of Phytochemicals from “Skimmia laureola, Nair” against “Black garden ant, Lasius niger” of Pakistan
A study was conducted to evaluate the toxicity and repellency of essential oils from root, stem and leaves of Nazar panra, Skimmia laureola (DC.) Zucc. Ex Walp. of family (Sapindales: Rutaceae) ver. Nair of Pakista...
Analytical, nutritional and biological evaluation of various brands of fortified and non-fortified wheat flour
In Pakistan, a funded flour fortification program was launched for malnourished population, residing mainly in rural low income areas, but the urban population having comparatively better nutritional as well as eco...
Angiotensin converting enzyme (ACE) gene expression in experimentally induced liver cirrhosis in rats
Angiotensin converting enzyme (ACE) is a key player of Renin Angiotensin System (RAS), involved in conversion of active product, angiotensin-II. Alterations in RAS have been implicated in the pathophysiology of var...