Immune response in a regressing compound dysplastic nevus
Journal Title: Nasza Dermatologia Online - Year 2018, Vol 9, Issue 1
Abstract
Atypical (dysplastic) melanocytic nevi are considered for many as an intermediate step in a clinicopathologic spectrum. Regression is often seen. A 45 year old male presented with a hyperpigmented macule on the patient’s back. Biopsies for hematoxylin and eosin (H&E) examination and immunohistochemistry (IHC) analysis were performed. The H&E staining demonstrated a compound dysplastic nevus. IHC stain shows stains with galectin 3, CD45, B-cell lymphoma 2 cyclooxygenase-2 ribosomal protein S6-ps240 (RIBO), CD68 and tyrosinase. Some stains were not only present in the tumor, but around it. We described a case of compound dysplastic nevi with a likely effectual early antitumoral response avoiding the growth to melanoma. The fundamental mechanism has not been elucidated, but our findings indicate a mix of inflammatory as well as immune response mediators maybe involved in the immune-based obliteration of melanocytes.
Authors and Affiliations
Ana Maria Abreu Velez
Keywords
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- EP ID EP284600
- DOI 10.7241/ourd.20181.18
- Views 67
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