ImmunoComb II Test in Detection of HCV Antibodies in Oral Fluid
Journal Title: Journal of Medical Science And clinical Research - Year 2015, Vol 3, Issue 6
Abstract
Objectives: a suitable, affordable, rapid and accurate test for HCV may be helpful in various clinical settings. The aim of the work is to evaluate the sensitivity, specificity and accuracy of ImmunoComb II HCV test in detection of HCV antibodies in oral fluid in comparison to serum 3rd generation ELISA test. Methods: this case control study included 40 patients with positive anti-HCV antibodies in the serum and positive HCV RNA PCR (Group I), compared to 20 patients with elevated liver enzymes, negative anti-HCV antibodies in serum and negative HCV RNA PCR (Group II), and to other 40 healthy controls (Group III). Results: ImmunoComb II HCV test of the oral fluid showed sensitivity: 67.5 %, specificity: 100%, PPV: 100%, NPV: 82% and diagnostic accuracy of 87% in diagnosis of HCV. Conclusion: the usage of ImmunoComb II for detection of HCV antibodies in oral fluid is promising and has a lot of advantages but needs more effort and more researches to increase its sensitivity
Authors and Affiliations
Mohamed A Mansour
Keywords
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