Abstract

Dermatological diseases with underlying immunological pathosis exhibiting similar clinical manifestations have challengedeven the veteran dermatologists in rendering diagnosis clinically, necessitating study of the skin lesions with immunofluro-scence. The technique is similar to immunochemistry where instead of enzymes antibodies are labelled with a fluorescentdye4. It probes the study of the cell and molecular biology. Immunofluorescence permit early diagnosis, treatment andsubsequent monitoring of disease activity in patient with potentially life threatening disease. It is widely used in the fieldof vesiculo-bullous lesions and other related oral dermatological disorders by demonstrating antibodies either in biopsytissue or in the serum separated from blood collected from the patients.

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