Immunogenicity of Hydrolysate Formulas in Children (Part 1). Review of 202 Reactions
Journal Title: Journal of Vaccines and Immunology - Year 2015, Vol 1, Issue 1
Abstract
Cow's milk (CM) protein hydrolyzed formulas (HFs) appeared in the 40's with the aim of decreasing or eliminating the allergenicity of CM proteins, and in addition of reducing the risk of sensitization. In recent years the so-called “hypoallergenic” (HA) formulas have been developed. The use of such HFs is based on the premise that predigested proteins, when fed as amino acids and peptides, provide nutrients in a not antigenic form. Thus, protein HFs have been classified as HA. These formulas are processed by heat and enzymatic hydrolysis, and the conformational and sequential structures are more or less changed. The formulas contain peptides of lower molecular weight (MW) than the native protein source, which are thought to be less immunogenic. HFs appear to be nutritionally adequate and infants generally gain weight until they refuse the formula because of its bad taste. However, caution should be taken when such formulas are given for prolonged periods since no data is available on nutritional assessment of infants exclusively fed HFs for several months. In this paper we report and discuss > 202 reactions to different HFs, including cases of anaphylactic shock and of apparent life-threatening events.
Authors and Affiliations
Cantani Arnaldo
Preparation and Application of two Monoclonal Antibodies against Canine Parvovirus Vaccine and Field Strains
Background: Canine parvovirus (CPV) emerged in 1970s as a highly infectious disease. CPV modified live vaccines have been widely used to control the disease. It is urgent to develop specific monoclonal antibodies to diff...
Introduction of Stereo Chemical Constraints into β -Amino Acid Residues
Over the last 20 years, a large body of work in the literature has focused on the folded structures formed by peptide sequences containing backbone homologated residues. Currently increasing interest in peptide based vac...
Safety of the Novel Vector Vaccine Against Brucella Abortus Based on Recombinant Influenza Viruses Expressing Brucella L7/L12 and OMP16 Proteins, in Cattle
This paper presents the results of a study of the safety of new vector vaccine against B. abortus based on recombinant influenza A subtype H5N1 or H1N1 (viral constructs vaccine formulation) viruses expressing Brucella r...
Mammalian Parasitic Vaccine: A Consolidated Exposition
Parasites are highly prevalent in livestock worldwide and infect over one fourth of the human population also. Parasites are successful in evading host immune responses, and vaccination can prove to be an effective way t...
IMS 4112 and VLP of HBV as Th1 Adjuvants for a Recombinant Protein of HIV-1
Background: Current thinking suggests that vaccination approaches against the HIV-1 should be directed to elicit a Th1 cell-mediated immunity, neutralizing antibodies and/or ADCC mediating antibody responses. Also, exper...