Immunoglobulin Expressions in Patients with Homozygous Sickle Cell Disease
Journal Title: Journal of Krishna Institute of Medical Sciences University - Year 2015, Vol 4, Issue 4
Abstract
Aim: The serum immunoglobulin (IgA, IgG, IgM) levels of sickle cell patients attending General Hospital Owerri, Nigeria were evaluated to determine whether or not the serum levels of these immunoglobulins were normal. Materials and Methods: One hundred confirmed sickle cell patients (HbSS), and thirty sickle cell patients in crisis age 5–30 years were selected. One hundred normal subjects (HbAA) age 5–30 years were used as control. Results: The levels of immunoglobulins (IgA and IgG) were significantly increased in sickle cell anaemia (p<0.05), except immunoglobulin M, when compared with the control (HbAA). However, the levels of immunoglobulins (IgA and IgG) were significantly increased in sickle cell crisis compared with sickle disease in steady state. Conclusion: The result suggests that alteration in immune response is associated with Sickle cell disease.
Authors and Affiliations
Johnkennedy Nnodim , Ibanga Imoh Etim , Ogbennaya Mba Arunsi , Emengaha Festus Chidi , Ejeatuluchukwu Obi , Amarachi Nwakanma
Keywords
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