Immunoglobulin GM and KM Allotypes Influence on the outcome of Hepatitis C Virus Treatment
Journal Title: Journal of Medical Science And clinical Research - Year 2014, Vol 2, Issue 6
Abstract
Hepatitis C virus (HCV) is an endemic problem in Egypt with genotype 4 affecting about 90% of the infected patients. The treatment with interferon (IFN) and ribavirin (RBV) is costly and has various side effects, so there is an urgent need for predictors of IFN response. IL-28B genotype was confirmed as a predictor of response to IFN treatment, but there are needs for other predictors. Patients and methods: DNA samples from 100 patients with chronic hepatitis C were allotyped for alleles at two GM loci: GM3/GM17, GM23+/GM23- and the KM locus: KM1/KM3, using PCR amplification, restriction analysis and sequencing. Based on sustained virological response (SVR), two groups were studied; group I consisted of 50 responder patients to pegylated IFN + RBV therapy while group II comprised of 50 non-responder patients to standard HCV therapy . Aim of the study: To detect immunoglobulin GM and KM allotypes—genetic markers of γ and κ chains, respectively— in Egyptian patients with chronic HCV and to assess their influence on treatment outcome. Results: There was a significant association between the KM genotypes and the treatment outcome. KM3 homozygosity was associated with five fold increase in response to treatment compared to KM1 allele carriers. Conclusion: Our findings suggest that KM genotypes can be used as genetic markers for prediction of chronic HCV treatment outcome
Authors and Affiliations
Manal Zaghloul Maharan
Keywords
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