IMMUNOHAEMATOLOGICAL AND BIOCHEMICAL CHARACTERISTICS IN RH-D HAEMOLYTIC DISEASE OF NEWBORN
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 78
Abstract
BACKGROUND Rh-D haemolytic disease of foetus and newborn (HDFN) is an ailment in which lifespan of infant’s erythrocytes were shortened by the action of placentally transferred maternal anti-D specific for inherited paternal red cell antigens. The aim of this study is to describe the immunological profile of Rh-D HDFN. Settings and Design- This was a descriptive study conducted among newborn with Rh-D HDFN. Setting was Depts. of Transfusion Medicine and Paediatrics in Govt. Medical College, Trivandrum. MATERIALS AND METHODS Enrolment of newborn was done according to the inclusion criteria. Demographic details, maternal history, bilirubin and haemoglobin levels were noted. Blood group and peak antibody level of mother were recorded. Direct antiglobulin test, blood grouping and elution was performed in infant. Statistical Analysis- All statistical data were analysed using SPSS software version 16. RESULTS In mothers of infants with Rh-D HDFN, 3 (6.8%) had a titre of 2, 6 (13.6%) had a titre of 4, 3 (6.8%) had a titre of 8, 2 (4.6%) had a titre of 16, 3 (6.8%) had a titre of 32, 7 (15.9%) had a titre of 64, 6 (13.6%) had a titre of 128, 7 (15.9%) had a titre of 256, 5 (11.4%) had a titre of 512 and 2 (4.6%) had titres of 1024. While considering DAT positivity in infants with Rh-D HDFN, 1 (2.3%) fell in grade 1, 33 (75%) in grade 2, 6 (13.6%) in grade 3 and 4 (9.1%) in grade 4 categories. CONCLUSION High titres of anti-D ranging from 128 - 1024 were observed in 45.5% of mothers of infants with Rh-D HDFN. While considering DAT positivity in infants with Rh-D HDFN, majority fell in grade 1 and 2 categories.
Authors and Affiliations
Sajith Vilambil, Meena Dharmadas, Kumari Krishnakumariamma Chakrapani Usha, Shaiji Panthiyil Shahulhameed, Chitra James, Anjaly Padmavilas Sasikala, Soonam John, Vineeth Rajagopal
Keywords
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- EP ID EP268044
- DOI 10.14260/jemds/2017/1205
- Views 91
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