Immunohistochemical aspects on (IL-6) and its relationship to pathological parameters and hormones receptors (ER, PR, HER-2) in breast cancer (BC)women from south of Iraq
Journal Title: International Journal Of Medical Science And Clinical Invention - Year 2017, Vol 4, Issue 3
Abstract
The aim of this study was to review the observations and information on relationship of preoperative level of (IL-6) with hormones receptors (ER,PR,HER-2) and the expression of these receptors in biopsies from patients with different stages and grades of disease by immunohistochemical method. In this study total number of (130)cases was analyzed and most patients diagnosed with stage (S111) then (S11)and (S1) with highly significant difference at (p≤ 0.05) and the same results was obtained from classified tumor grading with (BC)patients. The recent study evaluated level of (IL-6) in all (BC)patients ,the data showed highly significant difference and the mean level was increased in (71)case compared to control ,also we evaluated the relationship between tumor staging and grading with level of (IL-6) and data revealed to high level in (S111) patients while no signification between (S1,S3) ,the same results recorded between tumor grading and level (IL-6). Hormones receptors expression (ER,PR,HER-2) and its correlation with (IL-6)level was also determined ,the( IL-6) with (ER+)compared to (ER-) with high significance (p=0.00),the same results shown with (PR+) and(HER-2) expression and (IL-6)in all (BC)patients. The role of (IL-6) in (BC) immunity ,carcinogenesis ,cancer pathogenesis ,tumor initiation ,growth and metastasis .Results also explained correlate of (IL-6)with clinical staging and grading ,these findings Pointed to an important role in the progression of (BC) at least in patients with advanced disease stages.Data determined that the (ER+)positive tumor more reactive with(IL-6)then (PR+),(HER-2) which explained the effect of this factor on hormones receptors. Moreover present study found that the level of (IL-6) in (BC)recurrence may be differ according to(HER-2)status ,positive association with(BC) recurrence only among (HER2-)tumor with high mean level as compared to patients with(HER2+).Immunhistochemical staining was used in this study and results showed variable degree of staining Within invasive ductal and lobular carcinoma types compared to control.
Authors and Affiliations
Alaa R. Rashed , Maha K. Ibrahim , Maha SH. Hassan
Keywords
Related Articles
- EP ID EP313183
- DOI -
- Views 76
- Downloads 0
A study on the analysis of heart rate variability among women with gestational diabetes mellitus
Objective: To analyze heart rate variability (HRV) among women with gestational diabetes mellitus. Methods: A total of 60 women of >20 weeks gestational age were included (30 cases and 30 controls). All the subjects of t...
Acute Presentation of Ovarian Fibroma as a Pelvic Abscess – Case Report
We present a case of a female patient, who was referred to our department because of pain in the lower abdomen lasting for a couple of days. The preoperative abdominal computed tomography showed a well defined irregularl...
Evaluating Effects of Autologous Bone Marrow Injection Obtained From Reaming of Intramedullary Interlocking Nailing in Closed Diaphyseal Fresh Tibia Fractures in Fracture Healing
We performed a prospective, randomized controlled study on 60 patients with fresh closed diaphyseal tibial fractures to determine the effect of percutaneous autologous bone marrow injection on union rate. Sixty patients...
Clinical and Laboratory Profile of Patients Presenting With Warfarin Coagulation Abnormality Following Heart Valve Replacement- A Descriptive Study
Despite revolutionary changes in the field of medicine and eradication or prevention of many diseases worldwide in the past few decades, rheumatic heart disease (RHD) still remains as one of the largest preventable disea...
A Literature Review of the Effectiveness of CDS Vaccine Reminders on the Vaccination Rates
Some infectious and contagious diseases can spread like wildfire. Vaccinations can prevent this from happening. They can prevent two to three million deaths every year worldwide. Thirty-three percent of US children are i...