Immunohistochemical Comparison of the Expression of CD34 and CD105 in Odontogenic Keratocyst and Dentigerous Cyst
Journal Title: Journal of Dentistry, Shiraz University of Medical Sciences - Year 2017, Vol 18, Issue 1
Abstract
Statement of the Problem: Odontogenic keratocyst (OKC) is a developmental odontogenic cyst with specific histopathological features, high recurrence rate, and aggressive clinical behavior. Angiogenesis might be considered as an important factor for the growth, expansion, and distribution of this lesion. Purpose: The aim of the present study was to determine the mean vascular densities (MVD) of OKCs and dentigerous cysts to evaluate their relationship with the biologic behavior of these lesions. Materials and Method: In this cross-sectional analytical study, angiogenesis was assessed in OKC and dentigerous cyst by measuring the MVD. Immunohistochemistry was carried out using CD34 and CD105. The results were analyzed with independent samples t-test. The data were analyzed, setting p value at 0.05. Results: The MVDs with the use of CD34 and CD105 markers were significantly higher in OKC compared to dentigerous cyst (p< 0.05). In addition, MVDs obtained by CD105 in dentigerous cysts and OKC were significantly less than those based on CD34 (p< 0.05). Conclusion: Based on the results of the present study, it can be suggested that angiogenesis might be one of the possible mechanisms involved in higher aggressive biologic behavior and greater recurrence rate of OKC compared to dentigerous cysts.
Authors and Affiliations
Shokoofeh Jamshidi, Massoumeh Zargaran, Ghodratollah Roshanaei, Fatemeh Hadadi, Ali Dehghani Nazhvani
Keywords
Related Articles
- EP ID EP238838
- DOI -
- Views 101
- Downloads 0
Assessing the Accuracy of Caries Diagnosis in Bitewing Radiographs Using Different Reproduction Media
Statement of the Problem: After introducing digital radiography, practitioners started reading radiographs from computer monitors; however, many still prefer hard-copy radiographs. Purpose: This study aimed to assess th...
Shear Bond Strength of a Multi-Mode Adhesive to Bur-Cut and Er,Cr:YSGG Lased Dentin in Different Output Powers
Statement of the Problem: Universal or multi-mode adhesives are new adhesive systems that can be used in both etch-and-rinse (ER) and self-etch (SE) modes. Lesser technical sensitivity and dual use of these adhesives hav...
Efficacy of Human Umbilical Stem Cells Cultured on Polylactic/ Polyglycolic Acid Membrane in the Treatment of Multiple Gingival Recession Defects: a Randomized Controlled Clinical Study
Statement of the Problem: Recently allogenic mesenchymal stem cells are proposed to have multipotential progenitor cell capabilities to differentiate into cementoblasts, osteoblasts, and periodontal ligament fibroblasts....
A Rare Condition of Bimaxillary Primary Molar Taurodontism
Taurodontism is a relatively rare variance with a very low incidence in primary dentition and only a few cases have been reported in the literature. It stands a challenge when these teeth require pulp therapy. This case...
Granular Cell Odontogenic Tumor, an Extremely Rare Case Report
The granular cell odontogenic tumor is an extremely rare odontogenic neoplasm which about 38 cases has been reported with sufficient documentation in the literature. It has a prominent predilection to occur in the poster...