Immunohistochemical Expression of CD163 (Macrophage Marker) in Oral Epithelial Dysplasia Induced in Experimental Animals and its Relation to Microvessel Density (An animal Study)
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 6
Abstract
CD163, is significantly associated with the aggressive behavior of oral squamous cell carcinoma (OSCC). Although the phenotypes of tumour associated macrophages (TAMs) in different types of solid tumors have been extensively characterized, the phenotypes and functional properties of the TAMs that infiltrate premalignant lesions remain to be determined. The expression of the angiogenic activity has been shown to be an early and predictable characteristic of many pre- neoplastic cells, and may represent one of the earliest indications that a cell population has become committed to malignancy. Our study aims to Point out new markers that could be used for early detection of molecular changes prior to malignant transformation. A total of 48 adult male albino rats were selected. Our results showed a highly significant difference in both area percentage of CD163 immunoexpression and mean number of CD34+ blood vessels among the different experimental groups after 6 and 9 weeks of experiment
Authors and Affiliations
Mohammed Sheikh, Prof. Dr. Louloua Fathy, Ass. Prof. Dr. Nermine Raouf
Keywords
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- EP ID EP376073
- DOI 10.9790/0853-1706064163.
- Views 62
- Downloads 0
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