Immunohistochemical expression of Ki-67 in gall bladder carcinoma
Journal Title: Indian Journal of Pathology and Oncology - Year 2018, Vol 5, Issue 2
Abstract
Introduction Gall bladder carcinoma accounts for 0307 of all cancers and has a peak incidence among women aged 70 and 79 years Recently many molecular markers like Ki67 cyclin D1 MUC1 and p53 with prognostic impact on GBC have been described Ki67 is a proliferative marker which is expressed in all active phases of the cell cycle and it can be detected in the nucleus of tumour cells indicating its proliferative activityThe aim of this study is to evaluate the expression of Ki67 in carcinoma of gall bladder by immunohistochemistry and to correlate the mean Ki67 labelling index with the various histological grades of gallbladder carcinomaMaterials and Methods All the histopathologically proven cases of gall bladder malignancy from July 2014 to June 2017 n44 were examined for Ki67 expression immunohistochemicallyKi67 labelling index was calculated ANOVA test and independent lsquotrsquo test were applied to see correlation of Ki67 expression with various grades of gall bladder carcinomaResults The Ki67 labelling index was minimum in welldifferentiated adenocarcinoma of gall bladder and maximum in poorly differentiated adenocarcinoma of gall bladder The p value amongst these groups was found to be statistically significantly differentConclusion 8864 of Gall bladder carcinoma was positive for Ki67 and the Ki67 labelling index increased significantly as the histological grade increasedKeywordsnbspnbspKi67 Ki67 labelling index MIB labelling index Gall bladder carcinoma
Authors and Affiliations
Ankit Ojha1, Tanu Agrawal, Shubhanshu Gupta, Pragati Singh, Arushi Agarwal
Keywords
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- EP ID EP475481
- DOI 10.18231/2394-6792.2018.0033
- Views 56
- Downloads 0
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