Immunohistochemical Expression of Octamer-binding protein-4, in Oral Epithelial Dysplasia Induced in Experimental Rats (Animal Study)
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2018, Vol 17, Issue 7
Abstract
Octamer-binding protein-4 (OCT4) is an embryonic stem cell marker essential for the maintenance of embryonic stem cell (ESC) pluripotency and was believed to be crucial for progression of various human malignances (Jerabek et al., 2014). However, for the best of our knowledge comprehensive investigation of the role of OCT4 in oral epithelial dysplasia (OED) has not been carried out. That is why; it seemed interesting to study expression of OCT4 in different grades of OED, to point out new marker that could be used for early detection of molecular changes prior to malignant transformation. A total of 84 adult male albino rats were selected. Our results showed a highly significant difference in area percentage of OCT4immunoexpression among the different experimental groups after 6 and 9 weeks of experiment. We have concluded the possible role of OCT4 in early molecular events of tumorigenesis. Therefore, it may represent a promising early biomarker for carcinogenesis. In addition, the prognostic value of OCT4 in prediction of prognosis in OED was elucidated in the current work.
Authors and Affiliations
Maged Ali, Prof. Sawsan Naguib, Ass. Prof. Safa Fathy
Keywords
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- EP ID EP377395
- DOI 10.9790/0853-1707082646.
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