IMMUNOHISTOCHEMICAL EXPRESSION OF THE PROMISING THERAPEUTIC TARGET (HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 2/NEU) IN IRAQI PATIENTS WITH MEDULLOBLASTOMA
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 12
Abstract
Objectives: With the advent of ongoing novel modalities toward the treatment of human epidermal growth factor receptor 2 (HER2)/NEU - positive malignancies, the serious side effects of chemoradiotherapy have been minimized. Hence, this study was conducted to identify the patterns of immunohistochemical expression of the promising therapeutic target (HER2/NEU) among Iraqi patients with medulloblastoma in an attempt to provide basic histological information’s that would help in future clinical researches.Materials and Methods: In this retrospective study, 42 formalin - fixed paraffin - embedded tissue blocks represent cases of surgically removed medulloblastomas were retrieved from the archived materials in a specialized surgical hospital at Bagdad. The histological diagnosis had been revised, and all cases were stained by the immunohistochemical technique with HER2/NEU antibody and assessed independently by three pathologists.Results: Out of 42 cases, only two which represent 4.76% showed positive results manifested by a strong membranous staining when immunohistochemically evaluated using the same scoring system established for HER2/NEU in breast cancer. 14 cases (33.3%) showed incomplete membranous and five cases (11.9%) showed only cytoplasmic reaction patterns.Conclusion: The rate of expression of HER2/NEU in medulloblastoma among Iraqi patients is very low and found only in aggressive anaplastic histological type when immunohistochemically evaluated using the same scoring system established for HER2/NEU in breast cancer. However, a good number of negative cases showed cytoplasmic and incomplete membranous staining patterns highlighting the importance of establishing medulloblastoma - specific HER2/NEU scoring criteria and testing methods to discover the unique feature of expression of this therapeutic target in medulloblastoma.Â
Authors and Affiliations
Zainab Khalid Al Mukhtar, Zinah Hussein Abed Ali Al Saeg, Farah Falah Hasan
Keywords
Related Articles
- EP ID EP605225
- DOI 10.22159/ajpcr.2018.v11i12.28373
- Views 103
- Downloads 0
FACTORS INFLUENCING COMPLIANCE TO THERAPEUTIC REGIMEN AMONG PATIENTS WITH HYPERTENSION
Objectives: The objectives of the study were to identify the level of compliance to therapeutic regimen, assess the factors promoting and interfering compliance, and to find the association between level of compliance an...
EVALUATION OF NUCLEAR CHANGES IN THE BUCCAL EPITHELIAL CELLS OF TOBACCO USERS IN NNEWI, SOUTH EAST NIGERIA
Objective: The objective of this study was to evaluate nuclear changes in the buccal epithelial cells of commercial bus drivers using tobacco in Nnewi. Tobacco use constitutes a major risk factor of oral lesions, due to...
AWARENESS AND PRACTICE REGARDING CERVICAL CANCER PREVENTION AMONG FEMALE COLLEGE STUDENTS OF MANGALORE CITY, INDIA
Objective:To determine the awareness and practice of female college students in Mangalore in relation to cervical cancer. Methods:A cross-sectional study was carried out among 270 female students from various pre-univers...
Future Medical Doctors Are Ready to Prescribe Antimicrobials Safely and Rationally
Therefore, the answer remains in improving clinical pharmacology teaching and learning in undergraduate curriculum [40, 41]with necessary assessment program regarding prescribing skill [40]need to incorporate with the ho...
AN UPDATE ON PHARMACOLOGICAL PROFILE OF BOSWELLIA SERRATA
Boswellia serrata (Burseraceae) is the most ancient and respected herbs in Ayurveda. In Unani system of medicine, oleo-gum resin of Boswellia serrata named Kundur played a prime ingredient role in modern quality perfumes...